verinurad   Click here for help

GtoPdb Ligand ID: 9327

Synonyms: RDEA-3170 | RDEA3170
Compound class: Synthetic organic
Comment: Verinurad (RDEA3170) is an investigational selective uric acid reabsorption inhibitor, functionally inhibiting the URAT1 (SLC22A12) transporter and being investigated for clinical efficacy in controlling uric acid levels in patients with gout. URAT1 is the renal transporter that regulates uric acid excretion from the body. Verinurad is structurally related to lesinurad (RDEA594), a URAT1 inhibitor already approved for treating hyperuricemia in gout.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 99.28
Molecular weight 348.09
XLogP 4.05
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES N#Cc1ccc(c2c1cccc2)c1cnccc1SC(C(=O)O)(C)C
Isomeric SMILES N#Cc1ccc(c2c1cccc2)c1cnccc1SC(C(=O)O)(C)C
InChI InChI=1S/C20H16N2O2S/c1-20(2,19(23)24)25-18-9-10-22-12-17(18)16-8-7-13(11-21)14-5-3-4-6-15(14)16/h3-10,12H,1-2H3,(H,23,24)
InChI Key YYBOLPLTQDKXPM-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-[3-(4-cyanonaphthalen-1-yl)pyridin-4-yl]sulfanyl-2-methylpropanoic acid
International Nonproprietary Names Click here for help
INN number INN
9938 verinurad
Synonyms Click here for help
RDEA-3170 | RDEA3170
Database Links Click here for help
CAS Registry No. 1352792-74-5 (source: WHO INN record)
GtoPdb PubChem SID 318164846
PubChem CID 54767229
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