fosfomycin [Ligand Id: 10813] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1757 (J01XX01, Fosfocina, Fosfomycin, Fosfomycin sodium, Fosfomycin calcium, Monurol, ZTI-01, Zti-01)
  • UDP-N-acetylglucosamine 1-carboxyvinyltransferase in Escherichia coli K-12 [ChEMBL: CHEMBL1984] [UniProtKB: P0A749]
  • UDP-N-acetylglucosamine 1-carboxyvinyltransferase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) [ChEMBL: CHEMBL1075208] [UniProtKB: Q9HVW7]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
UDP-N-acetylglucosamine 1-carboxyvinyltransferase in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1984] [UniProtKB: P0A749]
ChEMBL Inhibition of Escherichia coli K-12 MBP-fused C-terminal His-tagged MurA (6508 to 7768 residues) using UNAG as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins in presence of PEP by malachite green dye based spectrophotometric method B 5.06 pIC50 8800 nM IC50 Bioorg Med Chem Lett (2017) 27: 944-949 [PMID:28077258]
ChEMBL Inhibition of Escherichia coli K12 Mur A in presence of UNAG B 6.93 pIC50 118 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 5605-5609 [PMID:16945528]
ChEMBL Inhibition of Escherichia coli MurA expressed in Escherichia coli BL21(lambdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis B 7 pIC50 100 nM IC50 Bioorg. Med. Chem. (2013) 21: 795-804 [PMID:23266177]
UDP-N-acetylglucosamine 1-carboxyvinyltransferase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075208] [UniProtKB: Q9HVW7]
ChEMBL Inhibition of Pseudomonas aeruginosa PAO1293 MurA in presence of UNAG B 4.98 pIC50 10500 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 5605-5609 [PMID:16945528]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]