fosfomycin [Ligand Id: 10813] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1757 (Calcium fosfomycin, Fosfocina, Fosfomycin, Fosfomycin calcium, Fosfomycin calcium hydrate, Fosfomycin sodium, J01XX01, Monurol, NSC-758170, Zti-01, ZTI-01) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1984] [UniProtKB: P0A749] | ||||||||
| ChEMBL | Inhibition of Escherichia coli K-12 MBP-fused C-terminal His-tagged MurA (6508 to 7768 residues) using UNAG as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins in presence of PEP by malachite green dye based spectrophotometric method | B | 5.06 | pIC50 | 8800 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 944-949 [PMID:28077258] |
| ChEMBL | Inhibition of Escherichia coli K12 Mur A in presence of UNAG | B | 6.93 | pIC50 | 118 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5605-5609 [PMID:16945528] |
| ChEMBL | Inhibition of Escherichia coli MurA expressed in Escherichia coli BL21(lambdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2013) 21: 795-804 [PMID:23266177] |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075208] [UniProtKB: Q9HVW7] | ||||||||
| ChEMBL | Inhibition of Pseudomonas aeruginosa PAO1293 MurA in presence of UNAG | B | 4.98 | pIC50 | 10500 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5605-5609 [PMID:16945528] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
