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ChEMBL ligand: CHEMBL594621 (15(s)-hete, AL-12959, Icomucret) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
ChEMBL | Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase | B | 5.14 | pIC50 | 7300 | nM | IC50 | J. Med. Chem. (1987) 30: 254-263 [PMID:3806609] |
ChEMBL | In vitro inhibitory activity against RBL-1 5-LO | B | 5.14 | pIC50 | 7300 | nM | IC50 | J. Med. Chem. (1987) 30: 574-580 [PMID:3820229] |
ChEMBL | Inhibition of rat neutrophil 5- Lipoxygenase (5-LO) | B | 5.84 | pIC50 | 1450 | nM | IC50 | J. Med. Chem. (1987) 30: 96-104 [PMID:3806607] |
BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1] | ||||||||
GtoPdb | - | - | 7.52 | pEC50 | >30 | nM | EC50 | J Biol Chem (2001) 276: 12454-9 [PMID:11278893] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]