15S-HETE [Ligand Id: 3401] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL594621 (15(s)-hete, AL-12959, Icomucret)
  • 5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
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  • BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase B 5.14 pIC50 7300 nM IC50 J. Med. Chem. (1987) 30: 254-263 [PMID:3806609]
ChEMBL In vitro inhibitory activity against RBL-1 5-LO B 5.14 pIC50 7300 nM IC50 J. Med. Chem. (1987) 30: 574-580 [PMID:3820229]
ChEMBL Inhibition of rat neutrophil 5- Lipoxygenase (5-LO) B 5.84 pIC50 1450 nM IC50 J. Med. Chem. (1987) 30: 96-104 [PMID:3806607]
BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1]
GtoPdb - - 7.52 pEC50 >30 nM EC50 J Biol Chem (2001) 276: 12454-9 [PMID:11278893]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]