15S-HETE [Ligand Id: 3401] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL594621 (15(s)-hete, AL-12959, Icomucret)
  • 5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
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  • BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase B 5.14 pIC50 7300 nM IC50 J Med Chem (1987) 30: 254-263 [PMID:3806609]
ChEMBL In vitro inhibitory activity against RBL-1 5-LO B 5.14 pIC50 7300 nM IC50 J Med Chem (1987) 30: 574-580 [PMID:3820229]
ChEMBL Inhibition of rat neutrophil 5- Lipoxygenase (5-LO) B 5.84 pIC50 1450 nM IC50 J Med Chem (1987) 30: 96-104 [PMID:3806607]
BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1]
GtoPdb - - 7.52 pEC50 >30 nM EC50 J Biol Chem (2001) 276: 12454-9 [PMID:11278893]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]