15S-HETE [Ligand Id: 3401] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL594621 (15(s)-hete, AL-12959, Icomucret) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
| ChEMBL | Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase | B | 5.14 | pIC50 | 7300 | nM | IC50 | J Med Chem (1987) 30: 254-263 [PMID:3806609] |
| ChEMBL | In vitro inhibitory activity against RBL-1 5-LO | B | 5.14 | pIC50 | 7300 | nM | IC50 | J Med Chem (1987) 30: 574-580 [PMID:3820229] |
| ChEMBL | Inhibition of rat neutrophil 5- Lipoxygenase (5-LO) | B | 5.84 | pIC50 | 1450 | nM | IC50 | J Med Chem (1987) 30: 96-104 [PMID:3806607] |
| BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1] | ||||||||
| GtoPdb | - | - | 7.52 | pEC50 | >30 | nM | EC50 | J Biol Chem (2001) 276: 12454-9 [PMID:11278893] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
