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ChEMBL ligand: CHEMBL227744 (L-Nitroarginine, L-N-Nitroarginine, L-Nw-Nitroarginine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
ChEMBL | Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrulline | B | 6.3 | pKi | 500 | nM | Ki | Bioorg Med Chem (2008) 16: 6193-6206 [PMID:18477512] |
GtoPdb | - | - | 7.82 | pKi | 15 | nM | Ki | J Med Chem (1998) 41: 2858-71 [PMID:9667974] |
ChEMBL | Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme. | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (1998) 41: 2858-2871 [PMID:9667974] |
ChEMBL | Inhibition of human nNOS by hemoglobin capture assay | B | 5.36 | pIC50 | 4400 | nM | IC50 | J Med Chem (2009) 52: 4533-4537 [PMID:19537690] |
ChEMBL | Inhibition of cloned (from RNA) human Neuronal nitric oxide synthase | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (1998) 41: 3675-3683 [PMID:9733492] |
ChEMBL | Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOS | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
ChEMBL | Concentration required to inhibit neuronal nitric oxide synthase | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
Neuronal NOS/Nitric-oxide synthase, brain in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4719] [GtoPdb: 1251] [UniProtKB: Q9Z0J4] | ||||||||
ChEMBL | Inhibition of neuronal nitric oxide synthase (nNOS) in mice | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 313-316 [PMID:14698148] |
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] | ||||||||
ChEMBL | Inhibition of rat recombinant nNOS | B | 5.34 | pKi | 4550 | nM | Ki | J Med Chem (2010) 53: 7804-7824 [PMID:20958055] |
ChEMBL | Inhibition of wild type rat nNOS by hemoglobin capture assay | B | 5.22 | pIC50 | 6000 | nM | IC50 | J Med Chem (2009) 52: 4533-4537 [PMID:19537690] |
ChEMBL | Inhibition of recombinant rat nNOS expressed in Escherichia coli by hemoglobin capture assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem (2012) 20: 2435-2443 [PMID:22370337] |
ChEMBL | Inhibition of rat nNOS expressed in HEK293T cells preincubated for 30 mins prior A23187-induced activation measured after 6 hrs by Griess assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem (2012) 20: 2435-2443 [PMID:22370337] |
ChEMBL | Inhibition of rat nNOS L337H mutant by hemoglobin capture assay | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2009) 52: 4533-4537 [PMID:19537690] |
ChEMBL | Inhibitory activity against isomeric form of Neuronal nitric oxide synthase measured by citrulline assay | B | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (1998) 41: 2636-2642 [PMID:9651169] |
ChEMBL | Compound was tested in vitro for inhibitory activity against nNOS (constitutive isoform found in neurons) | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 999-1002 |
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
GtoPdb | - | - | 7.52 | pKi | 30 | nM | Ki | J Med Chem (1998) 41: 2858-71 [PMID:9667974] |
ChEMBL | Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme. | B | 7.52 | pKi | 30 | nM | Ki | J Med Chem (1998) 41: 2858-2871 [PMID:9667974] |
ChEMBL | Inhibition of cloned (from RNA) human endothelial constitutive Endothelial nitric oxide synthase (heNOS) | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (1998) 41: 3675-3683 [PMID:9733492] |
ChEMBL | Inhibitory concentration against recombinant human Endothelial nitric oxide synthase | B | 6.49 | pIC50 | 320 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
ChEMBL | In vitro inhibition of endothelial nitric oxide synthase. | B | 6.49 | pIC50 | 320 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
Nitric-oxide synthase, endothelial in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4802] [UniProtKB: P29473] | ||||||||
ChEMBL | Inhibition of bovine recombinant eNOS | B | 6.12 | pKi | 750 | nM | Ki | J Med Chem (2010) 53: 7804-7824 [PMID:20958055] |
ChEMBL | Inhibition of bovine recombinant endothelial NOS by hemoglobin capture assay | B | 6.14 | pKi | 720 | nM | Ki | J Med Chem (2007) 50: 2089-2099 [PMID:17425297] |
ChEMBL | Inhibitory activity of conversion of radiolabeled arginine to citrulline by isomeric form of nitric oxide synthase Endothelial nitric oxide synthase from cultured bovine aortic endothelial cells | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (1998) 41: 2636-2642 [PMID:9651169] |
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
GtoPdb | - | - | 6.17 | pKi | 670 | nM | Ki | J Med Chem (1998) 41: 2858-71 [PMID:9667974] |
ChEMBL | Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme. | B | 6.17 | pKi | 670 | nM | Ki | J Med Chem (1998) 41: 2858-2871 [PMID:9667974] |
ChEMBL | Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS) | B | 5.12 | pIC50 | 7600 | nM | IC50 | J Med Chem (1998) 41: 3675-3683 [PMID:9733492] |
ChEMBL | Inhibitory concentration against human Inducible nitric oxide synthase | B | 5.26 | pIC50 | 5500 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1981-1984 [PMID:12781178] |
ChEMBL | In vitro inhibition of inducible nitric oxide synthase. | B | 5.26 | pIC50 | 5500 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2561-2564 [PMID:12182860] |
Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] | ||||||||
ChEMBL | Inhibition of mouse recombinant inducible NOS by hemoglobin capture assay | B | 5.37 | pKi | 4280 | nM | Ki | J Med Chem (2007) 50: 2089-2099 [PMID:17425297] |
ChEMBL | Inhibition of mouse recombinant iNOS | B | 6.24 | pKi | 570 | nM | Ki | J Med Chem (2010) 53: 7804-7824 [PMID:20958055] |
ChEMBL | Inhibition of inducible nitric oxide synthase (iNOS) in mice | B | 4.1 | pIC50 | 80000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 313-316 [PMID:14698148] |
ChEMBL | Inhibition of iNOS in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide overproduction incubated for 24 hrs by Griess assay | B | 4.56 | pIC50 | 27550 | nM | IC50 | Bioorg Med Chem (2020) 28: 115733-115733 [PMID:33065432] |
ChEMBL | Inhibition of inducible NOS mediated nitric oxide production in LPS-activated Kunming mouse macrophages | B | 4.83 | pIC50 | 14740 | nM | IC50 | Bioorg Med Chem (2008) 16: 578-585 [PMID:17937988] |
ChEMBL | Inhibition of radiolabeled arginine conversion to citrulline by isomeric form of Inducible nitric oxide synthase from mouse RAW 264.7 cells | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (1998) 41: 2636-2642 [PMID:9651169] |
ChEMBL | Compound was tested in vitro for inhibitory activity against inducible nitric oxide synthase | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 999-1002 |
ChEMBL | Tested for inhibition of mouse inducible nitric oxide synthase | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (1994) 37: 3886-3888 [PMID:7525961] |
Inducible NOS/Nitric oxide synthase, inducible in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3051] [GtoPdb: 1250] [UniProtKB: Q06518] | ||||||||
ChEMBL | Tested for inhibition of rat brain inducible nitric oxide synthase | B | 4.7 | pIC50 | 20000 | nM | IC50 | J Med Chem (1994) 37: 3886-3888 [PMID:7525961] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]