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ChEMBL ligand: CHEMBL1236620 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761] | ||||||||
ChEMBL | Inhibition of human recombinant CLK3 (275 to 632 amino acids) expressed in Escherichia coli BL21(DE3) preincubated for 10 mins prior to substrate addition by LDH assay | B | 6.28 | pIC50 | 530 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479] |
GtoPdb | - | - | 6.28 | pIC50 | 530 | nM | IC50 | Chem Biol (2011) 18: 67-76 [PMID:21276940] |
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
ChEMBL | Inhibition of DYRK1A (unknown origin) using YRASPSRPESPRPPA-NH2 as substrate preincubated for 10 mins prior to substrate addition by LDH assay | B | 7.26 | pIC50 | 55 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479] |
ChEMBL | Inhibition of DYRK1A (unknown origin) using YRASPSRPESPRPPA-amide as substrate preincubated for 10 mins followed by substrate addition and measured after 60 mins by caliper mobility shift assay | B | 7.26 | pIC50 | 55 | nM | IC50 | J Med Chem (2018) 61: 9791-9810 [PMID:29985601] |
GtoPdb | - | - | 7.26 | pIC50 | 55.2 | nM | IC50 | Chem Biol (2011) 18: 67-76 [PMID:21276940] |
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
ChEMBL | Inhibition of human recombinant CLK1 (148 to 484 amino acids) expressed in Escherichia coli BL21(DE3) using AFRREWSPGKEAKK as substrate preincubated for 10 mins prior to substrate addition by LDH assay | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479] |
GtoPdb | - | - | 7.71 | pIC50 | 19.7 | nM | IC50 | Chem Biol (2011) 18: 67-76 [PMID:21276940] |
ChEMBL | Inhibition of recombinant human CLK1 (130 to end residues) using ERMRPRKRQGSVRRRV as substrate incubated for 40 mins in presence of [gamma33P-ATP] by scintillation counting analysis | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem (2021) 31: 115962-115962 [PMID:33422908] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]