ChEMBL ligand: CHEMBL201747
glutaminyl-peptide cyclotransferase/Glutaminyl-peptide cyclotransferase in Human [ChEMBL: CHEMBL4508] [GtoPdb: 2411] [UniProtKB: Q16769] There should be some charts here, you may need to enable JavaScript!
glutaminyl-peptide cyclotransferase like/Glutaminyl-peptide cyclotransferase-like protein in Human [ChEMBL: CHEMBL3638349] [GtoPdb: 3289] [UniProtKB: Q9NXS2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
glutaminyl-peptide cyclotransferase/Glutaminyl-peptide cyclotransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4508] [GtoPdb: 2411] [UniProtKB: Q16769]
GtoPdb	-	-	7.22	pKi	60	nM	Ki	J Med Chem (2006) 49: 664-77 [PMID:16420052]
ChEMBL	Inhibitory activity against human glutaminyl cyclase	B	7.22	pKi	60	nM	Ki	J Med Chem (2006) 49: 664-677 [PMID:16420052]
ChEMBL	Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assay	B	7.22	pKi	60	nM	Ki	J Med Chem (2009) 52: 7069-7080 [PMID:19863057]
ChEMBL	Inhibition of human recombinant glutaminyl cyclase expressed in Escherichia coli using H-Gln-Gln-H substrate measured for 15 mins by spectrophotometry	B	5.28	pIC50	5300	nM	IC50	Bioorg Med Chem (2016) 24: 2280-2286 [PMID:27061673]
ChEMBL	Inhibition of recombinant human QC using H-Gln-AMC hydrobromide as fluorogenic substrate incubated for 6 hrs by fluorometric microplate reader analysis	B	7.54	pIC50	29	nM	IC50	ACS Med Chem Lett (2022) 13: 1459-1467 [PMID:36105338]
glutaminyl-peptide cyclotransferase like/Glutaminyl-peptide cyclotransferase-like protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3638349] [GtoPdb: 3289] [UniProtKB: Q9NXS2]
ChEMBL	Inhibition of recombinant human isoQC using H-Gln-AMC hydrobromide as fluorogenic substrate incubated for 6 hrs by fluorometric microplate reader analysis	B	6.45	pIC50	351	nM	IC50	ACS Med Chem Lett (2022) 13: 1459-1467 [PMID:36105338]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]