Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	361	2p22.2	QPCT	glutaminyl-peptide cyclotransferase
Mouse	-	362	17 E3	Qpct	glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
Rat	-	313	6q11	Qpct	glutaminyl-peptide cyclotransferase

Previous and Unofficial Names

GCT | glutaminyl cyclase | glutaminyl-tRNA cyclotransferase | QC

Database Links
Specialist databases
MEROPS	M28.974 (Hs)
Other databases
Alphafold	Q16769 (Hs), Q9CYK2 (Mm)
BRENDA	2.3.2.5
ChEMBL Target	CHEMBL4508 (Hs), CHEMBL4105900 (Mm)
Ensembl Gene	ENSG00000115828 (Hs), ENSMUSG00000024084 (Mm), ENSRNOG00000005705 (Rn)
Entrez Gene	25797 (Hs), 70536 (Mm), 313837 (Rn)
Human Protein Atlas	ENSG00000115828 (Hs)
KEGG Enzyme	2.3.2.5
KEGG Gene	hsa:25797 (Hs), mmu:70536 (Mm), rno:313837 (Rn)
OMIM	607065 (Hs)
Pharos	Q16769 (Hs)
RefSeq Nucleotide	NM_012413 (Hs), NM_027455 (Mm), NM_001134557 (Rn)
RefSeq Protein	NP_036545 (Hs), NP_081731 (Mm), NP_001128029 (Rn)
SynPHARM	82033 (in complex with PBD150)
UniProtKB	Q16769 (Hs), Q9CYK2 (Mm)
Wikipedia	QPCT (Hs)

Enzyme Reaction
EC Number: 2.3.2.5

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference PBD150 Hs Inhibition 7.2 pKi 1 ⤷ pKi 7.2 (Ki 6x10-8 M) [1]

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Cellular signalling