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glutaminyl-peptide cyclotransferase

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Target not currently curated in GtoImmuPdb

Target id: 2411

Nomenclature: glutaminyl-peptide cyclotransferase

Family: M28: Aminopeptidase Y

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 361 2p22.2 QPCT glutaminyl-peptide cyclotransferase
Mouse - 362 17 E3 Qpct glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
Rat - 313 6q11 Qpct glutaminyl-peptide cyclotransferase
Previous and Unofficial Names Click here for help
GCT | glutaminyl cyclase | glutaminyl-tRNA cyclotransferase | QC
Database Links Click here for help
Specialist databases
MEROPS M28.974 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.3.2.5

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
PBD150 Small molecule or natural product Ligand has a PDB structure Hs Inhibition 7.2 pKi 1
pKi 7.2 (Ki 6x10-8 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS

References

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1. Buchholz M, Heiser U, Schilling S, Niestroj AJ, Zunkel K, Demuth HU. (2006) The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J. Med. Chem., 49 (2): 664-77. [PMID:16420052]

How to cite this page

M28: Aminopeptidase Y: glutaminyl-peptide cyclotransferase. Last modified on 23/06/2015. Accessed on 01/12/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2411.