ChEMBL ligand: CHEMBL190461 (BTX-1204, BTX-1503, (-)-cannabidiol, Cannabidiol, Cannabidiol solution, Cardiolrx, (-)-cbd, CBD, .delta.1(2)-trans-cannabidiol, Epidiolex, GWP-42003, GWP42003, GWP-42003-P, GWP42003-P, (-)-trans-cannabidiol)
Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275] There should be some charts here, you may need to enable JavaScript!
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] There should be some charts here, you may need to enable JavaScript!
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] There should be some charts here, you may need to enable JavaScript!
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] There should be some charts here, you may need to enable JavaScript!
CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] CB1 receptor/Cannabinoid CB1 receptor in Rat [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] There should be some charts here, you may need to enable JavaScript!
CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] CB2 receptor/Cannabinoid CB2 receptor in Mouse [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936] There should be some charts here, you may need to enable JavaScript!
Caspase 1/Caspase-1 in Human [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] There should be some charts here, you may need to enable JavaScript!
Cholinesterase in Equus caballus [ChEMBL: CHEMBL5763] [UniProtKB: P81908] There should be some charts here, you may need to enable JavaScript!
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] There should be some charts here, you may need to enable JavaScript!
GPR55/G-protein coupled receptor 55 in Human [ChEMBL: CHEMBL1075322] [GtoPdb: 109] [UniProtKB: Q9Y2T6] There should be some charts here, you may need to enable JavaScript!
Heat sensitive channel TRPV3 in Rat [ChEMBL: CHEMBL3879847] [UniProtKB: Q4QYD9] There should be some charts here, you may need to enable JavaScript!
Hemozoin in Plasmodium falciparum [ChEMBL: CHEMBL613898] There should be some charts here, you may need to enable JavaScript!
H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
L-lactate dehydrogenase A chain in Human [ChEMBL: CHEMBL4835] [UniProtKB: P00338] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
N-Acylethanolamine acid amidase/N-acylsphingosine-amidohydrolase in Human [ChEMBL: CHEMBL4349] [GtoPdb: 1402] [UniProtKB: Q02083] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] There should be some charts here, you may need to enable JavaScript!
σ2/Sigma intracellular receptor 2 in Human [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] There should be some charts here, you may need to enable JavaScript!
diacylglycerol lipase α/Sn1-specific diacylglycerol lipase alpha in Human [ChEMBL: CHEMBL5545] [GtoPdb: 1396] [UniProtKB: Q9Y4D2] There should be some charts here, you may need to enable JavaScript!
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Rat [ChEMBL: CHEMBL5160] [GtoPdb: 485] [UniProtKB: Q6RI86] There should be some charts here, you may need to enable JavaScript!
TRPM8/Transient receptor potential cation channel subfamily M member 8 in Rat [ChEMBL: CHEMBL5011] [GtoPdb: 500] [UniProtKB: Q8R455] There should be some charts here, you may need to enable JavaScript!
TRPV2 in Human [GtoPdb: 508] [UniProtKB: Q9Y5S1] TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2] There should be some charts here, you may need to enable JavaScript!
TRPV4/Transient receptor potential cation channel subfamily V member 4 in Rat [ChEMBL: CHEMBL2775] [GtoPdb: 510] [UniProtKB: Q9ERZ8] There should be some charts here, you may need to enable JavaScript!
TRPV1/Vanilloid receptor in Human [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1] There should be some charts here, you may need to enable JavaScript!
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] There should be some charts here, you may need to enable JavaScript!
GPR18 in Human [GtoPdb: 89] [UniProtKB: Q14330] There should be some charts here, you may need to enable JavaScript!
TRPV3 in Rat [GtoPdb: 509] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured after 20 mins by Ellman's method	B	4.77	pIC50	17070	nM	IC50	Eur J Med Chem (2021) 223: 113735-113735 [PMID:34371367]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL	Inhibition of alpha2B receptor (unknown origin)	B	5.49	pKi	3200	nM	Ki	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL	Inhibition of alpha2C receptor (unknown origin)	B	5.43	pKi	3700	nM	Ki	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
ChEMBL	Inhibition of FAAH in rat brain membranes using [14C]-AEA as substrate measured after 30 mins by scintillation counting method	B	4.27	pIC50	53200	nM	IC50	J Nat Prod (2019) 82: 636-646 [PMID:30816712]
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL	Binding affinity towards cloned human Cannabinoid receptor 1	B	3.64	pKi	3.64	nM	Log Ki	J Med Chem (2000) 43: 2300-2309 [PMID:10882356]
ChEMBL	Binding affinity to human CB1 receptor	B	5.36	pKi	4350	nM	Ki	J Med Chem (2013) 56: 8224-8256 [PMID:23865723]
ChEMBL	Displacement of [3H]CP-55,940 from human CB1 receptor expressed in CHO cells incubated for 1 hr by liquid scintillation spectrometry	B	5.36	pKi	4350	nM	Ki	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
ChEMBL	Displacement of [3H]CP-55940 from human cannabinoid CB1 receptor expressed in CHO cells	B	5.62	pKi	2400	nM	Ki	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL	Displacement of [3H]-CP55940 from recombinant human CB1 receptor expressed in Sf9 cell membranes co-expressing Galphai3beta1gamma2 measured after 90 mins by scintillation counting method	B	5.84	pKi	1459	nM	Ki	J Nat Prod (2019) 82: 636-646 [PMID:30816712]
CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272]
ChEMBL	Displacement of [3H]HU243 from CB1 receptor in Sabra rat brain	B	5	pKi	>10000	nM	Ki	J Med Chem (2006) 49: 1113-1117 [PMID:16451075]
ChEMBL	Displacement of [3H]-HU-243 from CB1 receptor in Sabra rat brain synaptosomes after 90 mins	B	5	pKi	>10000	nM	Ki	ACS Med Chem Lett (2016) 7: 424-428 [PMID:27096053]
ChEMBL	Binding affinity for Cannabinoid receptor 1 by the ability to displace radiolabeled CP-55940 from purified rat forebrain synaptosomes	B	5.9	pKi	1265	nM	Ki	Bioorg Med Chem Lett (2002) 12: 3583-3586 [PMID:12443781]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL	Binding affinity towards cloned human cannabinoid receptor 2	B	3.46	pKi	3.46	nM	Log Ki	J Med Chem (2000) 43: 2300-2309 [PMID:10882356]
ChEMBL	Displacement of [3H]CP-55940 from human cannabinoid CB2 receptor expressed in CHO cells	B	5	pKi	10000	nM	Ki	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL	Binding affinity to human CB2 receptor	B	5.54	pKi	2860	nM	Ki	J Med Chem (2013) 56: 8224-8256 [PMID:23865723]
ChEMBL	Displacement of [3H]CP-55,940 from human CB2 receptor expressed in CHO cells incubated for 1 hr by liquid scintillation spectrometry	B	5.54	pKi	2860	nM	Ki	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
ChEMBL	Displacement of [3H]-CP55940 from recombinant human CB2 receptor expressed in Sf9 cell membranes co-expressing Galphai3beta1gamma2 measured after 90 mins by scintillation counting method	B	6.43	pKi	372	nM	Ki	J Nat Prod (2019) 82: 636-646 [PMID:30816712]
CB2 receptor/Cannabinoid CB2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936]
ChEMBL	Binding affinity for Cannabinoid receptor 2 by the ability to displace radiolabeled CP-55940 from mouse spleen synaptosomes	B	6.64	pKi	230	nM	Ki	Bioorg Med Chem Lett (2002) 12: 3583-3586 [PMID:12443781]
Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466]
ChEMBL	Binding affinity to recombinant human caspase-1 assessed as dissociation constant measured after 90 sec by SPR method	B	7.73	pKd	18.8	nM	Kd	J Nat Prod (2021) 84: 1563-1572 [PMID:33955754]
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured after 20 mins by Ellman's method	B	6.17	pIC50	670	nM	IC50	Eur J Med Chem (2021) 223: 113735-113735 [PMID:34371367]
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Inhibition of delta-type opioid receptor receptor (unknown origin)	B	5.19	pKi	6400	nM	Ki	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	Inhibition of D1 dopamine receptor (unknown origin)	B	5.57	pKi	2700	nM	Ki	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
GPR55/G-protein coupled receptor 55 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075322] [GtoPdb: 109] [UniProtKB: Q9Y2T6]
GtoPdb	-	-	6.46	pIC50	350	nM	IC50	Br J Pharmacol (2007) 152: 1092-101 [PMID:17876302]; Pharmacol Rev (2010) 62: 588-631 [PMID:21079038]
ChEMBL	Binding affinity to GPR55	B	6.35	pEC50	445	nM	EC50	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]
Heat sensitive channel TRPV3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879847] [UniProtKB: Q4QYD9]
ChEMBL	Antagonist activity at rat TRPV3 expressed in HEK293 cells assessed as inhibition of thymol-induced Ca2+ response preincubated for 5 mins followed by thymol addition by Fluo-4AM dye based fluorescence assay	B	6.12	pIC50	750	nM	IC50	J Nat Prod (2020) 83: 2727-2736 [PMID:32880179]
ChEMBL	Agonist activity at rat TRPV3 stably transfected in HEK293 cells assessed as increase in calcium influx in presence of ionomycin by Fluo-4-AM dye based spectrofluorimetric method	B	6.29	pEC50	510	nM	EC50	J Nat Prod (2020) 83: 2727-2736 [PMID:32880179]
Hemozoin in Plasmodium falciparum (target type: MACROMOLECULE) [ChEMBL: CHEMBL613898]
ChEMBL	Inhibition of Beta-hematin in Plasmodium falciparum cells assessed as hemozoin formation after 32 hrs by NP40 detergent-mediated assay	B	4.29	pIC50	51100	nM	IC50	Bioorg Med Chem Lett (2021) 54: 128442-128442 [PMID:34763083]
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
ChEMBL	Inhibition of histamine H3 receptor (unknown origin)	B	5.51	pKi	3100	nM	Ki	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Inhibition of kappa-type opioid receptor (unknown origin)	B	5.64	pKi	2300	nM	Ki	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
L-lactate dehydrogenase A chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4835] [UniProtKB: P00338]
ChEMBL	Non-competitive inhibition of human LDHA assessed as reduction in lactate production using pyruvate as substrate in presence of NADH by Lineweaver-Burk plot analysis	B	4.62	pKi	24000	nM	Ki	J Nat Prod (2021) 84: 1469-1477 [PMID:33887133]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Inhibition of mu-type opioid receptor (unknown origin)	B	5.89	pKi	1300	nM	Ki	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
N-Acylethanolamine acid amidase/N-acylsphingosine-amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4349] [GtoPdb: 1402] [UniProtKB: Q02083]
ChEMBL	Inhibition of recombinant human NAAA expressed in HEK293 cells using [14C]-N-palmitoylethanolamine as substrate measured after 30 mins by beta-counting method	B	4	pIC50	>100000	nM	IC50	J Nat Prod (2019) 82: 636-646 [PMID:30816712]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Agonist activity at GAL4-tagged PPARgamma (unknown origin) transiently expressed in HEK293T cells co-transfected with GAL4-tagged luc incubated for 6 hrs by dual luciferase reporter gene assay	B	4.6	pEC50	>25000	nM	EC50	J Nat Prod (2020) 83: 1711-1715 [PMID:32315173]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54	F	5.39	pIC50	4100	nM	IC50	Bioorg Med Chem Lett (2021) 54: 128442-128442 [PMID:34763083]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Displacement of [3H]8-OH-DPAT from human 5-HT1a receptor expressed in CHO cells incubated for 30 mins by liquid scintillation counting method	B	5.1	pEC50	8000	nM	EC50	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL	Displacement of [3H] ketanserin from rat 5-HT2aR expressed in mouse NIH/3T3 cells incubated for 30 mins by liquid scintillation counting method	B	4.49	pEC50	32000	nM	EC50	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL	Inhibition of 5-HT2C (unknown origin)	B	5.96	pKi	1100	nM	Ki	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2]
ChEMBL	Inhibition of sigma2 receptor (unknown origin)	B	5.47	pKi	3400	nM	Ki	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
diacylglycerol lipase α/Sn1-specific diacylglycerol lipase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5545] [GtoPdb: 1396] [UniProtKB: Q9Y4D2]
ChEMBL	Inhibition of recombinant human DAGLalpha expressed in COS7 cells using [14C]-oleoyl-2-arachidonoyl-glycerol as substrate measured after 20 mins by beta-counting method	B	4	pIC50	>100000	nM	IC50	J Nat Prod (2019) 82: 636-646 [PMID:30816712]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5160] [GtoPdb: 485] [UniProtKB: Q6RI86]
ChEMBL	Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allylisothiocyanate-induced Ca2+ response preincubated for 5 mins followed by allylisothiocyanate addition by Fluo-4AM dye based fluorescence assay	B	6.35	pIC50	450	nM	IC50	J Nat Prod (2020) 83: 2727-2736 [PMID:32880179]
ChEMBL	Agonist activity at rat TRPA1 stably transfected in HEK293 cells assessed as increase in calcium influx in presence of allylisothiocyanate by Fluo-4-AM dye based spectrofluorimetric method	B	6.32	pEC50	480	nM	EC50	J Nat Prod (2020) 83: 2727-2736 [PMID:32880179]
ChEMBL	Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx	F	7.02	pEC50	96	nM	EC50	J Med Chem (2010) 53: 5085-5107 [PMID:20356305]
TRPM8/Transient receptor potential cation channel subfamily M member 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5011] [GtoPdb: 500] [UniProtKB: Q8R455]
ChEMBL	Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced Ca2+ response preincubated for 5 mins followed by icilin addition by Fluo-4AM dye based fluorescence assay	B	5.55	pIC50	2800	nM	IC50	J Nat Prod (2020) 83: 2727-2736 [PMID:32880179]
TRPV2 in Human [GtoPdb: 508] [UniProtKB: Q9Y5S1]
GtoPdb	-	-	4.5	pEC50	31700	nM	EC50	J Neurosci (2008) 28: 6231-8 [PMID:18550765]
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2]
ChEMBL	Antagonist activity at rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ response preincubated for 5 mins followed by LPC addition by Fluo-4AM dye based fluorescence assay	B	5.96	pIC50	1100	nM	IC50	J Nat Prod (2020) 83: 2727-2736 [PMID:32880179]
GtoPdb	-	-	5.43	pEC50	3700	nM	EC50	J Neurosci (2008) 28: 6231-8 [PMID:18550765]
ChEMBL	Agonist activity at rat TRPV2 stably transfected in HEK293 cells assessed as increase in calcium influx in presence of ionomycin by Fluo-4-AM dye based spectrofluorimetric method	B	5.92	pEC50	1200	nM	EC50	J Nat Prod (2020) 83: 2727-2736 [PMID:32880179]
TRPV4/Transient receptor potential cation channel subfamily V member 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2775] [GtoPdb: 510] [UniProtKB: Q9ERZ8]
ChEMBL	Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK1016790A-induced Ca2+ response preincubated for 5 mins followed by GSK1016790A addition by Fluo-4AM dye based fluorescence assay	B	5.23	pIC50	5900	nM	IC50	J Nat Prod (2020) 83: 2727-2736 [PMID:32880179]
ChEMBL	Agonist activity at rat TRPV4 stably transfected in HEK293 cells assessed as increase in calcium influx in presence of ionomycin by Fluo-4-AM dye based spectrofluorimetric method	B	6.05	pEC50	900	nM	EC50	J Nat Prod (2020) 83: 2727-2736 [PMID:32880179]
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1]
ChEMBL	Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ response preincubated for 5 mins followed by capsaicin addition by Fluo-4AM dye based fluorescence assay	B	5.43	pIC50	3700	nM	IC50	J Nat Prod (2020) 83: 2727-2736 [PMID:32880179]
ChEMBL	Agonist activity at human TRPV1 stably transfected in HEK293 cells assessed as increase in calcium influx in presence of ionomycin by Fluo-4-AM dye based spectrofluorimetric method	B	5.39	pEC50	4100	nM	EC50	J Nat Prod (2020) 83: 2727-2736 [PMID:32880179]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
ChEMBL	Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rat ventricular myocytes	F	7	pIC50	100	nM	IC50	IC50 data for the L-type calcium channel extracted from a set of literature articles
GPR18 in Human [GtoPdb: 89] [UniProtKB: Q14330]
GtoPdb	-	-	4.29	pEC50	51100	nM	EC50	Br J Pharmacol (2012) 165: 2414-24 [PMID:21595653]
TRPV3 in Rat [GtoPdb: 509]
GtoPdb	Calcium imaging	-	5.43	pEC50	3700	nM	EC50	Acta Physiol (Oxf) (2012) 204: 255-66 [PMID:21726418]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]