ChEMBL ligand: CHEMBL679 (Anapen, Ana-Guard, Ana-Kit, Sus-phrine sulfite free, Adrenalin, Epipen, Anaphylactic Shock Drug Kit, Riddobron, Symjepi, Epinephrine HCl, Epi E Z Pen Jr, Sus-Phrine Sulfite-Free, Bronkaid Mist, Epinephrine, Adrenaline, Gppe Inh Soln, Simplene, Riddofan, Adren Co, Epipen E Z Pen, Primatene, Epipen Jr, Medihaler-epi, Rybarvin, Epipen Jr., Twinject 0.15, Eppy, Asthmahaler, Levo-Methylaminoethanolcatechol, Asma-Vydrin, Soln Made To Rybarvin For, Auvi-Q, Emerade, Twinject 0.3, Primatene Mist, Twinject, Brovon, NSC-62786, Sus-Phrine, Jext, Adrenaclick)
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] 1 CHEMBL679_lig_chart_1 Alpha-1a adrenergic receptor HumanRat There should be some charts here, you may need to enable JavaScript!
α1B-adrenoceptor in Human [GtoPdb: 23] [UniProtKB: P35368] α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823] 2 CHEMBL679_lig_chart_2 α1B-adrenoceptor HumanRat There should be some charts here, you may need to enable JavaScript!
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] α1D-adrenoceptor in Rat [GtoPdb: 24] [UniProtKB: P23944] 3 CHEMBL679_lig_chart_3 Alpha-1d adrenergic receptor HumanRat There should be some charts here, you may need to enable JavaScript!
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] 4 CHEMBL679_lig_chart_4 Alpha-2a adrenergic receptor Human There should be some charts here, you may need to enable JavaScript!
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] 5 CHEMBL679_lig_chart_5 Alpha-2b adrenergic receptor Human There should be some charts here, you may need to enable JavaScript!
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] 6 CHEMBL679_lig_chart_6 Alpha-2c adrenergic receptor Human There should be some charts here, you may need to enable JavaScript!
Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530] This target only has 0 pki data point 7 CHEMBL679_lig_chart_7 Arachidonate 15-lipoxygenase Rabbit There should be some charts here, you may need to enable JavaScript!
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588] β1-adrenoceptor/Beta-1 adrenergic receptor in Rat [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090] Beta-1 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73] 8 CHEMBL679_lig_chart_8 β1-adrenoceptor HumanRatGuinea pig There should be some charts here, you may need to enable JavaScript!
β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] Beta-2 adrenergic receptor in Dog [ChEMBL: CHEMBL2289] [UniProtKB: P54833] β2-adrenoceptor/Beta-2 adrenergic receptor in Rat [ChEMBL: CHEMBL3754] [GtoPdb: 29] [UniProtKB: P10608] Beta-2 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] 9 CHEMBL679_lig_chart_9 Beta-2 adrenergic receptor HumanDogRatGuinea pig There should be some charts here, you may need to enable JavaScript!
β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] This target only has 1 pki data point 10 CHEMBL679_lig_chart_10 Beta-3 adrenergic receptor Human There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] This target only has 0 pki data point 11 CHEMBL679_lig_chart_11 Dopamine D1 receptor Human There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] This target only has 1 pki data point 12 CHEMBL679_lig_chart_12 Dopamine D2 receptor Human There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL	Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101	B	5.7	pKi	2000	nM	Ki	J. Med. Chem. (1988) 31: 1972-1977 [PMID:2845082]
GtoPdb	-	-	6.5	pKi	-	-	-	Mol. Pharmacol. (1995) 48: 250-8 [PMID:7651358]; Br. J. Pharmacol. (1995) 116: 1611-8 [PMID:8564227]
ChEMBL	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	F	6.4	pEC50	400	nM	EC50	J. Med. Chem. (1988) 31: 1972-1977 [PMID:2845082]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL	DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)	B	6.6	pKi	254	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)	B	6.2	pIC50	628	nM	IC50	DrugMatrix in vitro pharmacology data
α1B-adrenoceptor in Human [GtoPdb: 23] [UniProtKB: P35368]
GtoPdb	-	-	6.5	pKi	-	-	-	Mol. Pharmacol. (1995) 48: 250-8 [PMID:7651358]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	B	6.01	pKi	977	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	B	5.75	pIC50	1766	nM	IC50	DrugMatrix in vitro pharmacology data
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL	DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)	B	6.66	pKi	221	nM	Ki	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	7.2	pKi	-	-	-	Mol. Pharmacol. (1995) 48: 250-8 [PMID:7651358]; Br. J. Pharmacol. (1995) 116: 1611-8 [PMID:8564227]
ChEMBL	DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)	B	6.35	pIC50	449	nM	IC50	DrugMatrix in vitro pharmacology data
α1D-adrenoceptor in Rat [GtoPdb: 24] [UniProtKB: P23944]
GtoPdb	-	-	6.3	pKi	-	-	-	Mol. Pharmacol. (1994) 46: 929-36 [PMID:7969082]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	B	6.56	pKi	276	nM	Ki	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	7.4	pKi	-	-	-	Biochim. Biophys. Acta (1998) 1448: 135-46 [PMID:9824686]; Biochem. Pharmacol. (1998) 55: 1035-43 [PMID:9605427]
ChEMBL	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	B	6.13	pIC50	737	nM	IC50	DrugMatrix in vitro pharmacology data
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
GtoPdb	-	-	5.2	pKi	-	-	-	Biochem. Pharmacol. (1998) 55: 1035-43 [PMID:9605427]
ChEMBL	DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)	B	6.4	pKi	397	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)	B	6.06	pIC50	869	nM	IC50	DrugMatrix in vitro pharmacology data
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
GtoPdb	-	-	5.8	pKi	-	-	-	Biochem. Pharmacol. (1998) 55: 1035-43 [PMID:9605427]
ChEMBL	DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)	B	6.45	pKi	356	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)	B	5.61	pIC50	2449	nM	IC50	DrugMatrix in vitro pharmacology data
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL	DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)	B	5.48	pIC50	3279	nM	IC50	DrugMatrix in vitro pharmacology data
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb	-	-	6	pKi	-	-	-	Proc. Natl. Acad. Sci. U.S.A. (1988) 85: 9494-8 [PMID:2849109]; Naunyn Schmiedebergs Arch. Pharmacol. (2004) 369: 151-9 [PMID:14730417]
β1-adrenoceptor/Beta-1 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090]
ChEMBL	Binding of [3H]dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes	B	5.68	pKi	2100	nM	Ki	J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
ChEMBL	Displacement of [3H]dihydroalprenolol from adrenergic beta 1 receptor of rat cerebral cortical membranes	B	5.92	pKi	1200	nM	Ki	J. Med. Chem. (1993) 36: 3947-3955 [PMID:8254623]
ChEMBL	Binding of [3H]dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes	B	5.96	pKi	1100	nM	Ki	J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73]
ChEMBL	Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenolol	B	5.52	pKi	3000	nM	Ki	J. Med. Chem. (1988) 31: 1972-1977 [PMID:2845082]
ChEMBL	Effective dose required to stimulate contractions in isolated guinea pig atrium.	F	6.36	pEC50	436	nM	EC50	J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
ChEMBL	Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria	F	6.59	pEC50	260	nM	EC50	J. Med. Chem. (1988) 31: 1972-1977 [PMID:2845082]
ChEMBL	Effective dose required to stimulate contractions in isolated guinea pig atrium.	F	7.82	pEC50	15	nM	EC50	J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL	Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM	B	6.2	pKd	630.96	nM	Kd	Bioorg. Med. Chem. Lett. (2013) 23: 5376-5381 [PMID:23954364]
ChEMBL	Binding affinity to human adrenergic beta2 receptor	B	6.2	pKd	630	nM	Kd	Eur. J. Med. Chem. (2009) 44: 2840-2846 [PMID:19168263]
GtoPdb	-	-	6.2	pKi	-	-	-	Proc. Natl. Acad. Sci. U.S.A. (1988) 85: 9494-8 [PMID:2849109]; J. Biol. Chem. (1997) 272: 23871-9 [PMID:9295336]; Naunyn Schmiedebergs Arch. Pharmacol. (2004) 369: 151-9 [PMID:14730417]
ChEMBL	Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cells	B	6.44	pKi	360	nM	Ki	Bioorg. Med. Chem. (2016) 24: 2641-2653 [PMID:27132867]
ChEMBL	DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177)	B	6.71	pKi	196	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177)	B	6.55	pIC50	284	nM	IC50	DrugMatrix in vitro pharmacology data
Beta-2 adrenergic receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2289] [UniProtKB: P54833]
ChEMBL	Binding of [3H]dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes	B	5.96	pKi	1100	nM	Ki	J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
ChEMBL	Binding of [3H]dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes	B	6.18	pKi	660	nM	Ki	J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
β2-adrenoceptor/Beta-2 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3754] [GtoPdb: 29] [UniProtKB: P10608]
ChEMBL	Binding affinity against adrenergic beta 2 receptor versus 1 nM [3H]dihydroalprenolol in rat cerebral cerebellar membranes	B	6.14	pKi	720	nM	Ki	J. Med. Chem. (1993) 36: 3947-3955 [PMID:8254623]
Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4]
ChEMBL	Effective dose for relaxation of guinea pig trachea.	F	6.36	pEC50	436	nM	EC50	J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
ChEMBL	Effective dose for relaxation of guinea pig trachea.	F	7.82	pEC50	15	nM	EC50	J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
GtoPdb	-	-	3.9	pKi	-	-	-	Naunyn Schmiedebergs Arch. Pharmacol. (2004) 369: 151-9 [PMID:14730417]
ChEMBL	Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay	F	7.31	pEC50	49	nM	EC50	Bioorg. Med. Chem. (2008) 16: 2473-2488 [PMID:18083578]
ChEMBL	Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method	F	7.51	pEC50	31	nM	EC50	Bioorg. Med. Chem. (2008) 16: 2473-2488 [PMID:18083578]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	B	4.26	pKd	55000	nM	Kd	J. Med. Chem. (1996) 39: 850-859 [PMID:8632409]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Displacement of [3H]spiperone from human D2S receptor expressed in CHO cells	B	6.04	pKi	910	nM	Ki	Bioorg. Med. Chem. (2016) 24: 2641-2653 [PMID:27132867]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]