A-841720 [Ligand Id: 3953] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL386565 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255] | ||||||||
| GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2005) 48: 7374-88 [PMID:16279797] |
| ChEMBL | Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization | F | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2005) 48: 7374-7388 [PMID:16279797] |
| mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385] | ||||||||
| ChEMBL | Inhibition of rat mGluR1 | B | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2008) 43: 1025-1034 [PMID:17822809] |
| ChEMBL | Inhibition of rat mGluR1 | B | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2008) 43: 1025-1034 [PMID:17822809] |
| GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 |
Eur J Pharmacol (2008) 580: 314-21 [PMID:18054908]; Bioorg Med Chem Lett (2006) 16: 4936-40 [PMID:16809035] |
| ChEMBL | Antagonist activity at rat mGluR1 expressed in 1321N1 cells | F | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 4936-4940 [PMID:16809035] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
| ChEMBL | Antagonist activity at human mGluR5 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization | F | 6.47 | pIC50 | 342 | nM | IC50 | J Med Chem (2005) 48: 7374-7388 [PMID:16279797] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| ChEMBL | Antagonist activity at rat mGluR5 expressed in 1321N1 cells | F | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 4936-4940 [PMID:16809035] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
