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ChEMBL ligand: CHEMBL386565 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255] | ||||||||
GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2005) 48: 7374-88 [PMID:16279797] |
ChEMBL | Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization | F | 8 | pIC50 | 10 | nM | IC50 | J. Med. Chem. (2005) 48: 7374-7388 [PMID:16279797] |
mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385] | ||||||||
ChEMBL | Inhibition of rat mGluR1 | B | 8 | pIC50 | 10 | nM | IC50 | Eur. J. Med. Chem. (2008) 43: 1025-1034 [PMID:17822809] |
ChEMBL | Inhibition of rat mGluR1 | B | 8 | pIC50 | 10 | nM | IC50 | Eur. J. Med. Chem. (2008) 43: 1025-1034 [PMID:17822809] |
GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 |
Eur J Pharmacol (2008) 580: 314-21 [PMID:18054908]; Bioorg Med Chem Lett (2006) 16: 4936-40 [PMID:16809035] |
ChEMBL | Antagonist activity at rat mGluR1 expressed in 1321N1 cells | F | 9 | pIC50 | 1 | nM | IC50 | Bioorg. Med. Chem. Lett. (2006) 16: 4936-4940 [PMID:16809035] |
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
ChEMBL | Antagonist activity at human mGluR5 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization | F | 6.47 | pIC50 | 342 | nM | IC50 | J. Med. Chem. (2005) 48: 7374-7388 [PMID:16279797] |
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
ChEMBL | Antagonist activity at rat mGluR5 expressed in 1321N1 cells | F | 5 | pIC50 | >10000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2006) 16: 4936-4940 [PMID:16809035] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]