A-841720 [Ligand Id: 3953] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL386565
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Human [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385]
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  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Human [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
GtoPdb - - 8 pIC50 10 nM IC50 J Med Chem (2005) 48: 7374-88 [PMID:16279797]
ChEMBL Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization F 8 pIC50 10 nM IC50 J Med Chem (2005) 48: 7374-7388 [PMID:16279797]
mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385]
ChEMBL Inhibition of rat mGluR1 B 8 pIC50 10 nM IC50 Eur J Med Chem (2008) 43: 1025-1034 [PMID:17822809]
ChEMBL Inhibition of rat mGluR1 B 8 pIC50 10 nM IC50 Eur J Med Chem (2008) 43: 1025-1034 [PMID:17822809]
GtoPdb - - 9 pIC50 1 nM IC50 Eur J Pharmacol (2008) 580: 314-21 [PMID:18054908];
Bioorg Med Chem Lett (2006) 16: 4936-40 [PMID:16809035]
ChEMBL Antagonist activity at rat mGluR1 expressed in 1321N1 cells F 9 pIC50 1 nM IC50 Bioorg Med Chem Lett (2006) 16: 4936-4940 [PMID:16809035]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
ChEMBL Antagonist activity at human mGluR5 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization F 6.47 pIC50 342 nM IC50 J Med Chem (2005) 48: 7374-7388 [PMID:16279797]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
ChEMBL Antagonist activity at rat mGluR5 expressed in 1321N1 cells F 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2006) 16: 4936-4940 [PMID:16809035]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]