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ChEMBL ligand: CHEMBL521589 (Bambuterol) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
ChEMBL | Inhibition of electric eel AChE using S-acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of human blood AChE using acetylthiocholine as substrate | B | 4.52 | pIC50 | 30000 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
ChEMBL | Inhibition of AChE (unknown origin) | B | 4.52 | pIC50 | 30000 | nM | IC50 | Eur J Med Chem (2017) 132: 294-309 [PMID:28371641] |
ChEMBL | Inhibition of AChE (unknown origin) | B | 4.52 | pIC50 | 30000 | nM | IC50 | Bioorg Med Chem Lett (2022) 61: 128602-128602 [PMID:35124202] |
ChEMBL | Inhibition of human erythrocytes AChE using S-acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136] | ||||||||
ChEMBL | Inhibition of rat AChE | B | 4.52 | pIC50 | 30000 | nM | IC50 | Eur J Med Chem (2022) 240: 114606-114606 [PMID:35858523] |
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
ChEMBL | Inhibition of human plasma BuChE using S-butyrylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 8.37 | pIC50 | 4.29 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
GtoPdb | - | - | 8.5 | pIC50 | - | - | - | Neurochem Res (2003) 28: 515-22 [PMID:12675140] |
ChEMBL | Inhibition of human blood BuChE using butyrylthiocholine as substrate | B | 8.52 | pIC50 | 3 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
ChEMBL | Inhibition of BuChE (unknown origin) | B | 8.52 | pIC50 | 3 | nM | IC50 | Eur J Med Chem (2017) 132: 294-309 [PMID:28371641] |
ChEMBL | Inhibition of BuchE (unknown origin) | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2022) 61: 128602-128602 [PMID:35124202] |
Butyrylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1] | ||||||||
ChEMBL | Inhibition of rat BChE | B | 8.52 | pIC50 | 3 | nM | IC50 | Eur J Med Chem (2022) 240: 114606-114606 [PMID:35858523] |
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 6.92 | pIC50 | 119.33 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] | ||||||||
ChEMBL | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.7 | pIC50 | 2000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]