bambuterol [Ligand Id: 6601] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL521589 (Bambuterol)
  • Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
  • acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
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  • butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL Inhibition of electric eel AChE using S-acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method B 4 pIC50 >100000 nM IC50 Eur J Med Chem (2017) 126: 61-71 [PMID:27744187]
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL Inhibition of human blood AChE using acetylthiocholine as substrate B 4.52 pIC50 30000 nM IC50 Eur J Med Chem (2017) 126: 61-71 [PMID:27744187]
ChEMBL Inhibition of AChE (unknown origin) B 4.52 pIC50 30000 nM IC50 Eur J Med Chem (2017) 132: 294-309 [PMID:28371641]
ChEMBL Inhibition of human erythrocytes AChE using S-acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method B 5 pIC50 >10000 nM IC50 Eur J Med Chem (2017) 126: 61-71 [PMID:27744187]
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL Inhibition of human plasma BuChE using S-butyrylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method B 8.37 pIC50 4.29 nM IC50 Eur J Med Chem (2017) 126: 61-71 [PMID:27744187]
GtoPdb - - 8.5 pIC50 - - - Neurochem Res (2003) 28: 515-22 [PMID:12675140]
ChEMBL Inhibition of human blood BuChE using butyrylthiocholine as substrate B 8.52 pIC50 3 nM IC50 Eur J Med Chem (2017) 126: 61-71 [PMID:27744187]
ChEMBL Inhibition of BuChE (unknown origin) B 8.52 pIC50 3 nM IC50 Eur J Med Chem (2017) 132: 294-309 [PMID:28371641]
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method B 6.92 pIC50 119.33 nM IC50 Eur J Med Chem (2017) 126: 61-71 [PMID:27744187]
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
ChEMBL DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) B 5.7 pIC50 2000 nM IC50 DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]