ampicillin [Ligand Id: 10896] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL174 (Alpha-Aminobenzylpenicillin, Amcill, Amfipen, Aminobenzylpenicillin, Aminobenzylpenicillin trihydrate, Ampicilina, Ampicillin, Ampicillin/ampicillin trihydrate, Ampicillin (anhydrous), Ampicillin anhydrous, Ampicillin, anhydrous, Ampicilline, Ampicillin hydrate, Ampicillin trihydrate, Ampicillinum, Ampilar, Anhydrous ampicillin, AY-6108, Britcin, BRL-1341, NSC-528986, Omnipen (ampicillin), Omnipen-N, P-50, Penbritin, Penbritin-S, Pfizerpen-a, Pfizerpen-A, Poly-cillin, Polycillin, Polycillin-N, Polycillin-Prb, Principen, Principen '125', Principen '250', Principen '500', Probampacin, Redicilin, Semicillin, Tokiocillin, Totacillin, Totacillin-N, Ultrabion, Vidopen, WY 5103) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6] | ||||||||
| ChEMBL | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured MDH refolding after 20 to 40 mins by spectrometric analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2018) 61: 10651-10664 [PMID:30392371] |
| ChEMBL | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding after 45 mins by spectrometric analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2018) 61: 10651-10664 [PMID:30392371] |
| HSP60/HSP10 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106131] [UniProtKB: P10809, P61604] | ||||||||
| ChEMBL | Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding after 40 to 60 mins by spectrometric analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2018) 61: 10651-10664 [PMID:30392371] |
| Thiosulfate sulfurtransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295835] [UniProtKB: Q16762] | ||||||||
| ChEMBL | Inhibition of refolded rhodanese (unknown origin) preincubated with Escherichia coli GroEL/GroES for 60 mins in absence of compound followed by compound addition by spectrometric analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2018) 61: 10651-10664 [PMID:30392371] |
| TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763] | ||||||||
| ChEMBL | Binding affinity to human recombinant Tie2 by SPR assay | B | 4.09 | pKd | 82000 | nM | Kd | Bioorg Med Chem Lett (2012) 22: 2388-2392 [PMID:22406116] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
