ampicillin [Ligand Id: 10896] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL174 (Penbritin-S, Vidopen, Totacillin, P-50, Principen, Britcin, NSC-528986, Ampilar, Amcill, Ampicillin, Polycillin-Prb, Ampicillin trihydrate, Pfizerpen-A, Probampacin, Ampicillin/ampicillin trihydrate, Polycillin, Principen '500', AY-6108, Principen '250', Pfizerpen-a, Aminobenzylpenicillin, Totacillin-N, WY 5103, Polycillin-N, Anhydrous ampicillin, Penbritin, Omnipen (ampicillin), Principen '125', Amfipen, BRL-1341, Omnipen-N, Alpha-Aminobenzylpenicillin, Omnipen)
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  • TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6]
ChEMBL Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured MDH refolding after 20 to 40 mins by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]
ChEMBL Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding after 45 mins by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]
HSP60/HSP10 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106131] [UniProtKB: P10809, P61604]
ChEMBL Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding after 40 to 60 mins by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]
Thiosulfate sulfurtransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295835] [UniProtKB: Q16762]
ChEMBL Inhibition of refolded rhodanese (unknown origin) preincubated with Escherichia coli GroEL/GroES for 60 mins in absence of compound followed by compound addition by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
ChEMBL Binding affinity to human recombinant Tie2 by SPR assay B 4.09 pKd 82000 nM Kd Bioorg. Med. Chem. Lett. (2012) 22: 2388-2392 [PMID:22406116]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]