ampicillin [Ligand Id: 10896] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL174 (Alpha-Aminobenzylpenicillin, Amcill, Amfipen, Aminobenzylpenicillin, Aminobenzylpenicillin trihydrate, Ampicillin, Ampicillin/ampicillin trihydrate, Ampicillin anhydrous, Ampicillin (anhydrous), Ampicillin, anhydrous, Ampicillin hydrate, Ampicillin trihydrate, Ampicillinum, Ampilar, Anhydrous ampicillin, AY-6108, Britcin, BRL-1341, NSC-528986, Omnipen, Omnipen (ampicillin), Omnipen-N, P-50, Penbritin, Penbritin-S, Pfizerpen-a, Pfizerpen-A, Polycillin, Poly-cillin, Polycillin-N, Polycillin-Prb, Principen, Principen '125', Principen '250', Principen '500', Probampacin, Redicilin, Semicillin, Tokiocillin, Totacillin, Totacillin-N, Ultrabion, Vidopen, WY 5103)
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6]
ChEMBL Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured MDH refolding after 20 to 40 mins by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]
ChEMBL Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding after 45 mins by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]
HSP60/HSP10 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106131] [UniProtKB: P10809, P61604]
ChEMBL Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding after 40 to 60 mins by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]
Thiosulfate sulfurtransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295835] [UniProtKB: Q16762]
ChEMBL Inhibition of refolded rhodanese (unknown origin) preincubated with Escherichia coli GroEL/GroES for 60 mins in absence of compound followed by compound addition by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
ChEMBL Binding affinity to human recombinant Tie2 by SPR assay B 4.09 pKd 82000 nM Kd Bioorg. Med. Chem. Lett. (2012) 22: 2388-2392 [PMID:22406116]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]