ampicillin [Ligand Id: 10896] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL174 (Alpha-Aminobenzylpenicillin, Amcill, Amfipen, Aminobenzylpenicillin, Aminobenzylpenicillin trihydrate, Ampicillin, Ampicillin/ampicillin trihydrate, Ampicillin (anhydrous), Ampicillin anhydrous, Ampicillin, anhydrous, Ampicillin hydrate, Ampicillin trihydrate, Ampicillinum, Ampilar, Anhydrous ampicillin, AY-6108, Britcin, BRL-1341, NSC-528986, Omnipen, Omnipen (ampicillin), Omnipen-N, P-50, Penbritin, Penbritin-S, Pfizerpen-a, Pfizerpen-A, Poly-cillin, Polycillin, Polycillin-N, Polycillin-Prb, Principen, Principen '125', Principen '250', Principen '500', Probampacin, Redicilin, Semicillin, Tokiocillin, Totacillin, Totacillin-N, Ultrabion, Vidopen, WY 5103) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6] | ||||||||
| ChEMBL | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured MDH refolding after 20 to 40 mins by spectrometric analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2018) 61: 10651-10664 [PMID:30392371] |
| ChEMBL | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding after 45 mins by spectrometric analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2018) 61: 10651-10664 [PMID:30392371] |
| HSP60/HSP10 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106131] [UniProtKB: P10809, P61604] | ||||||||
| ChEMBL | Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding after 40 to 60 mins by spectrometric analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2018) 61: 10651-10664 [PMID:30392371] |
| Thiosulfate sulfurtransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295835] [UniProtKB: Q16762] | ||||||||
| ChEMBL | Inhibition of refolded rhodanese (unknown origin) preincubated with Escherichia coli GroEL/GroES for 60 mins in absence of compound followed by compound addition by spectrometric analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2018) 61: 10651-10664 [PMID:30392371] |
| TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763] | ||||||||
| ChEMBL | Binding affinity to human recombinant Tie2 by SPR assay | B | 4.09 | pKd | 82000 | nM | Kd | Bioorg Med Chem Lett (2012) 22: 2388-2392 [PMID:22406116] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
