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ChEMBL ligand: CHEMBL316069 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130] | ||||||||
ChEMBL | Binding affinity towards Alpha-1 adrenergic receptor of calf brain cortex using [3H]prazosin | B | 5.6 | pKd | 5.6 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
ChEMBL | Binding affinity towards Alpha-1 adrenergic receptor of calf brain cortex using [3H]prazosin | B | 6 | pKd | 6 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
Alpha-2a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4744] [UniProtKB: Q28838] | ||||||||
ChEMBL | Binding affinity towards Alpha-2 adrenergic receptor of calf brain cortex using [3H]clonidine | B | 6 | pKd | 6 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
ChEMBL | Binding affinity towards Alpha-2 adrenergic receptor of calf brain cortex using [3H]clonidine | B | 6.5 | pKd | 6.5 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
Dopamine D1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2967] [UniProtKB: Q95136] | ||||||||
ChEMBL | Binding affinity towards Dopamine receptor D1 of calf striatal tissue using [3H]SCH-23390 | B | 5 | pKd | <5 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
ChEMBL | Binding affinity towards Dopamine receptor D1 of calf striatal tissue using [3H]SCH-23390 | B | 5 | pKd | <5 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
Dopamine D2 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3998] [UniProtKB: P20288] | ||||||||
ChEMBL | Binding affinity towards Dopamine receptor D2 of calf striatal tissue using [3H]spiperone | B | 5 | pKd | <5 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
ChEMBL | Binding affinity towards Dopamine receptor D2 of calf striatal tissue using [3H]spiperone | B | 5 | pKd | <5 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
ChEMBL | Binding affinity towards 5-hydroxytryptamine 1A receptor in pig frontal cortex membranes using [8H]-OH-DPAT | B | 5 | pKd | <5 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
ChEMBL | Binding affinity towards 5-hydroxytryptamine 1A receptor in pig frontal cortex membranes using [8H]-OH-DPAT | B | 6.1 | pKd | 6.1 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] | ||||||||
ChEMBL | Binding affinity towards 5-hydroxytryptamine 2C receptor of porcine choroid plexus using [3H]mesulergine | B | 4.6 | pKd | 4.6 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
ChEMBL | Binding affinity towards 5-hydroxytryptamine 2C receptor of porcine choroid plexus using [3H]mesulergine | B | 6.7 | pKd | 6.7 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
ChEMBL | Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex membranes using [125]ICYP | B | 5.4 | pKd | 5.4 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
GtoPdb | - | - | 6.3 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
ChEMBL | Binding affinity towards 5-hydroxytryptamine 3 receptor in membranes of N1E-115 neuroblastoma cells using [3H]-ICS 205-930; Not determined | B | 5.7 | pKd | 5.7 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
ChEMBL | Binding affinity towards 5-hydroxytryptamine 3 receptor in membranes of N1E-115 neuroblastoma cells using [3H]-ICS 205-930 | B | 6.2 | pKd | 6.2 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
ChEMBL | Binding affinity analysed on 5-HT 2A in rat stomach fundus. | B | 6.2 | pKi | 630.96 | nM | Ki | J Med Chem (1996) 39: 2773-2780 [PMID:8709108] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
ChEMBL | Binding affinity towards 5-hydroxytryptamine 1D receptor in calf caudate membranes using [3H]5-HT; Not determined | B | 6.7 | pKd | 6.7 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
ChEMBL | Binding affinity towards 5-hydroxytryptamine 1D receptor in calf caudate membranes using [3H]5-HT | B | 7.8 | pKd | 7.8 | - | pKD | J Med Chem (1995) 38: 28-33 [PMID:7837236] |
GtoPdb | - | - | 8.1 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909] | ||||||||
ChEMBL | Binding affinity analysed on 5-HT 2C in rat stomach fundus. | B | 7.8 | pKi | 15.85 | nM | Ki | J Med Chem (1996) 39: 2773-2780 [PMID:8709108] |
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
GtoPdb | - | - | 6.7 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]