SDZ SER-082 [Ligand Id: 195] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL316069
  • Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
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  • Alpha-2a adrenergic receptor in Bovine [ChEMBL: CHEMBL4744] [UniProtKB: Q28838]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
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  • 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL Binding affinity towards Alpha-1 adrenergic receptor of calf brain cortex using [3H]prazosin B 5.6 pKd 5.6 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
ChEMBL Binding affinity towards Alpha-1 adrenergic receptor of calf brain cortex using [3H]prazosin B 6 pKd 6 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
Alpha-2a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4744] [UniProtKB: Q28838]
ChEMBL Binding affinity towards Alpha-2 adrenergic receptor of calf brain cortex using [3H]clonidine B 6 pKd 6 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
ChEMBL Binding affinity towards Alpha-2 adrenergic receptor of calf brain cortex using [3H]clonidine B 6.5 pKd 6.5 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
Dopamine D1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2967] [UniProtKB: Q95136]
ChEMBL Binding affinity towards Dopamine receptor D1 of calf striatal tissue using [3H]SCH-23390 B 5 pKd <5 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
ChEMBL Binding affinity towards Dopamine receptor D1 of calf striatal tissue using [3H]SCH-23390 B 5 pKd <5 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
Dopamine D2 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3998] [UniProtKB: P20288]
ChEMBL Binding affinity towards Dopamine receptor D2 of calf striatal tissue using [3H]spiperone B 5 pKd <5 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
ChEMBL Binding affinity towards Dopamine receptor D2 of calf striatal tissue using [3H]spiperone B 5 pKd <5 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1A receptor in pig frontal cortex membranes using [8H]-OH-DPAT B 5 pKd <5 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1A receptor in pig frontal cortex membranes using [8H]-OH-DPAT B 6.1 pKd 6.1 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL Binding affinity towards 5-hydroxytryptamine 2C receptor of porcine choroid plexus using [3H]mesulergine B 4.6 pKd 4.6 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
ChEMBL Binding affinity towards 5-hydroxytryptamine 2C receptor of porcine choroid plexus using [3H]mesulergine B 6.7 pKd 6.7 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex membranes using [125]ICYP B 5.4 pKd 5.4 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb - - 6.3 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL Binding affinity towards 5-hydroxytryptamine 3 receptor in membranes of N1E-115 neuroblastoma cells using [3H]-ICS 205-930; Not determined B 5.7 pKd 5.7 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
ChEMBL Binding affinity towards 5-hydroxytryptamine 3 receptor in membranes of N1E-115 neuroblastoma cells using [3H]-ICS 205-930 B 6.2 pKd 6.2 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
ChEMBL Binding affinity analysed on 5-HT 2A in rat stomach fundus. B 6.2 pKi 630.96 nM Ki J. Med. Chem. (1996) 39: 2773-2780 [PMID:8709108]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1D receptor in calf caudate membranes using [3H]5-HT; Not determined B 6.7 pKd 6.7 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1D receptor in calf caudate membranes using [3H]5-HT B 7.8 pKd 7.8 - pKD J. Med. Chem. (1995) 38: 28-33 [PMID:7837236]
GtoPdb - - 8.1 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
ChEMBL Binding affinity analysed on 5-HT 2C in rat stomach fundus. B 7.8 pKi 15.85 nM Ki J. Med. Chem. (1996) 39: 2773-2780 [PMID:8709108]
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
GtoPdb - - 6.7 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]