compound 31 [PMID: 20936789] [Ligand Id: 8180] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1276848
  • checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
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  • NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
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  • NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
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  • polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL Inhibition of CHK1 B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2010) 53: 7682-7698 [PMID:20936789]
NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
ChEMBL Inhibition of NEK1 after 1 hr at room temperature by caliper method B 6.77 pIC50 170 nM IC50 J. Med. Chem. (2010) 53: 7682-7698 [PMID:20936789]
GtoPdb - - 6.77 pIC50 170 nM IC50 J. Med. Chem. (2010) 53: 7682-98 [PMID:20936789]
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
ChEMBL Inhibition of NEK2 autophosphorylation after 2 hrs by DELFIA assay B 6.52 pIC50 300 nM IC50 J. Med. Chem. (2010) 53: 7682-7698 [PMID:20936789]
ChEMBL Inhibition of NEK2 by microfluidic assay B 6.64 pIC50 230 nM IC50 J. Med. Chem. (2010) 53: 7682-7698 [PMID:20936789]
GtoPdb - - 6.64 pIC50 230 nM IC50 J. Med. Chem. (2010) 53: 7682-98 [PMID:20936789]
ChEMBL Inhibition of NEK2 assessed as inhibition of substrate phosphorylation B 6.7 pIC50 200 nM IC50 J. Med. Chem. (2010) 53: 7682-7698 [PMID:20936789]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL Inhibition of PLK1 after 75 mins at room temperature by caliper method B 4.71 pIC50 19400 nM IC50 J. Med. Chem. (2010) 53: 7682-7698 [PMID:20936789]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]