ChEMBL ligand: CHEMBL1276848
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] There should be some charts here, you may need to enable JavaScript!
NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6] There should be some charts here, you may need to enable JavaScript!
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955] There should be some charts here, you may need to enable JavaScript!
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL	Inhibition of CHK1	B	4	pIC50	>100000	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]
NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
ChEMBL	Inhibition of NEK1 after 1 hr at room temperature by caliper method	B	6.77	pIC50	170	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]
GtoPdb	-	-	6.77	pIC50	170	nM	IC50	J Med Chem (2010) 53: 7682-98 [PMID:20936789]
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
ChEMBL	Inhibition of NEK2 autophosphorylation after 2 hrs by DELFIA assay	B	6.52	pIC50	300	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]
ChEMBL	Inhibition of NEK2 by microfluidic assay	B	6.64	pIC50	230	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]
GtoPdb	-	-	6.64	pIC50	230	nM	IC50	J Med Chem (2010) 53: 7682-98 [PMID:20936789]
ChEMBL	Inhibition of NEK2 assessed as inhibition of substrate phosphorylation	B	6.7	pIC50	200	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL	Inhibition of PLK1 after 75 mins at room temperature by caliper method	B	4.71	pIC50	19400	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]