compound 1b [PMID: 16290936] [Ligand Id: 8613] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL114161 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
| ChEMBL | Inhibitory concentration against recombinant human cathepsin B was determined in a fluorescence assay using 10 uM Cbz-Phe-Arg-AMC as substrate | B | 6.34 | pIC50 | 460 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 3425-3429 [PMID:15177446] |
| ChEMBL | Inhibition of recombinant human cathepsin B in a fluorescence assay | B | 6.34 | pIC50 | 460 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 978-983 [PMID:16290936] |
| cathepsin H/Cathepsin H in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2225] [GtoPdb: 2349] [UniProtKB: P09668] | ||||||||
| GtoPdb | - | - | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 978-83 [PMID:16290936] |
| ChEMBL | Inhibition of recombinant human cathepsin H in a fluorescence assay | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 978-983 [PMID:16290936] |
| cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235] | ||||||||
| GtoPdb | - | - | 8.74 | pKi | 1.8 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 978-83 [PMID:16290936] |
| ChEMBL | Inhibitory concentration against recombinant human cathepsin K determined in a fluorescence assay using 10 uM Cbz-Phe-Arg-AMC as substrate | B | 8.74 | pIC50 | 1.8 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 3425-3429 [PMID:15177446] |
| ChEMBL | Inhibition of recombinant human cathepsin K in a fluorescence assay | B | 8.74 | pIC50 | 1.8 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 978-983 [PMID:16290936] |
| cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] | ||||||||
| ChEMBL | Inhibitory concentration against recombinant human cathepsin L was determined in a fluorescence assay using 5 uM Cbz-Phe-Arg-AMC as substrate | B | 6.13 | pIC50 | 740 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 3425-3429 [PMID:15177446] |
| ChEMBL | Inhibition of recombinant human cathepsin L in a fluorescence assay | B | 6.13 | pIC50 | 740 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 978-983 [PMID:16290936] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
