(+)-sulpiride [Ligand Id: 960] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL196677 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of cloned human carbonic anhydrase II | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2005) 48: 5721-5727 [PMID:16134940] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of catalytic domain of human recombinant carbonic anhydrase IX | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2005) 48: 5721-5727 [PMID:16134940] |
| D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| GtoPdb | - | - | 8.22 | pKi | 6 | nM | Ki | J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand. | B | 5.57 | pKi | 2700 | nM | Ki | J Med Chem (1991) 34: 261-267 [PMID:1825115] |
| GtoPdb | - | - | 7 | pKi | - | - | - | Nature (1990) 347: 146-51 [PMID:1975644] |
| D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| GtoPdb | - | - | 8.1 | pKi | 7.99 | nM | Ki | Mol Pharmacol (1993) 43: 749-54 [PMID:8099194] |
| D3 receptor in Rat [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
| GtoPdb | - | - | 6.4 | pKi | - | - | - | Nature (1990) 347: 146-51 [PMID:1975644] |
| D4 receptor in Human [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| GtoPdb | - | - | 5.66 | pKi | 2200 | nM | Ki | Mol Pharmacol (1996) 50: 1658-64 [PMID:8967990] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
