deoxycholic acid [Ligand Id: 610] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL406393 (DWJ-211, Kybella, Deoxycholic Acid, ATX-101, NSC-8797, Desoxycholic acid, Deoxycholate, DWJ211)
  • Farnesoid X receptor/Bile acid receptor FXR in Human [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1]
There should be some charts here, you may need to enable JavaScript!
  • GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
There should be some charts here, you may need to enable JavaScript!
  • Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • FPR1 in Human [GtoPdb: 222] [UniProtKB: P21462]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Farnesoid X receptor/Bile acid receptor FXR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1]
ChEMBL Agonist activity at human recombinant FXR expressed in HEK293 cells coexpressing CMX-GAL4N by luciferase reporter gene assay F 4.3 pEC50 50000 nM EC50 Bioorg. Med. Chem. Lett. (2012) 22: 3962-3966 [PMID:22583617]
ChEMBL Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotin-labeled SRC-1 recruitment after 30 mins by Alpha Screen assay B 4.35 pEC50 45000 nM EC50 Eur J Med Chem (2018) 144: 349-358 [PMID:29275233]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL Agonist activity at human TGR5 expressed in CHO cells by luciferase assay F 5.9 pEC50 1250 nM EC50 J. Med. Chem. (2008) 51: 1831-1841 [PMID:18307294]
GtoPdb - - 6.2 pEC50 - - - Biochem. Biophys. Res. Commun. (2002) 298: 714-9 [PMID:12419312]
Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908]
ChEMBL TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells F 5.2 pKi 6300 nM Ki Am. J. Physiol. (1998) 274: G157-G169 [PMID:9458785]
ChEMBL TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells F 5.2 pKi 6300 nM Ki Am. J. Physiol. (1998) 274: G157-G169 [PMID:9458785]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability by parasite lactate dehydrogenase assay F 4.03 pIC50 93600 nM IC50 Eur. J. Med. Chem. (2015) 100: 10-17 [PMID:26063305]
Steroid Delta-isomerase in Pseudomonas putida (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321641] [UniProtKB: P07445]
ChEMBL Binding affinity to Pseudomonas putida KSI by surface plasmon resonance analysis B 4.8 pKd 16000 nM Kd J. Med. Chem. (2013) 56: 2155-2159 [PMID:23419007]
ChEMBL Binding affinity to Pseudomonas putida KSI by isothermal titration calorimetry B 4.8 pKd 16000 nM Kd J. Med. Chem. (2013) 56: 2155-2159 [PMID:23419007]
Vitamin D receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1977] [GtoPdb: 605] [UniProtKB: P11473]
ChEMBL Antagonist activity against VP16 tagged-VDR-LBD (unknown origin) expressed in HEK293T cells assessed as inhibition of 1,25-dihydroxyvitamin D3-induced SRC1 coactivator peptide recruitment after 16 hrs by luciferase reporter gene based two hybrid assay B 4.3 pIC50 >50000 nM IC50 Eur. J. Med. Chem. (2016) 109: 238-246 [PMID:26774929]
FPR1 in Human [GtoPdb: 222] [UniProtKB: P21462]
GtoPdb - - 4 pKi - - - Biochem. Pharmacol. (2002) 63: 533-41 [PMID:11853704]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]