ChEMBL ligand: CHEMBL2420382
Leucyl-cysteinyl aminopeptidase/Cystinyl aminopeptidase in Human [ChEMBL: CHEMBL2693] [GtoPdb: 1570] [UniProtKB: Q9UIQ6] There should be some charts here, you may need to enable JavaScript!
Endoplasmic reticulum aminopeptidase 1 in Human [ChEMBL: CHEMBL5939] [GtoPdb: 1566] [UniProtKB: Q9NZ08] There should be some charts here, you may need to enable JavaScript!
Endoplasmic reticulum aminopeptidase 2 in Human [ChEMBL: CHEMBL5043] [GtoPdb: 1567] [UniProtKB: Q6P179] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Leucyl-cysteinyl aminopeptidase/Cystinyl aminopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2693] [GtoPdb: 1570] [UniProtKB: Q9UIQ6]
GtoPdb	-	-	5.22	pIC50	6000	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4832-6 [PMID:23916253]
ChEMBL	Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin after 5 to 10 mins by fluorescence assay	B	5.22	pIC50	6000	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4832-4836 [PMID:23916253]
Endoplasmic reticulum aminopeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5939] [GtoPdb: 1566] [UniProtKB: Q9NZ08]
ChEMBL	Inhibition of recombinant ERAP1 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin after 5 to 10 mins by fluorescence assay	B	5.59	pIC50	2600	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4832-4836 [PMID:23916253]
GtoPdb	-	-	5.59	pIC50	2600	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4832-6 [PMID:23916253]
Endoplasmic reticulum aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5043] [GtoPdb: 1567] [UniProtKB: Q6P179]
GtoPdb	-	-	5.05	pIC50	8900	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4832-6 [PMID:23916253]
ChEMBL	Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Arginyl-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin after 5 to 10 mins by fluorescence assay	B	5.05	pIC50	8900	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4832-4836 [PMID:23916253]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]