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ChEMBL ligand: CHEMBL274826 (Androstenedione) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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synuclein alpha/Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840] | ||||||||
ChEMBL | Inhibition of alpha-synuclein aggregation (unknown origin) incubated for 8 days by thioflavin S based fluorescence assay | B | 4.07 | pIC50 | 85900 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] | ||||||||
ChEMBL | Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) | B | 5.89 | pIC50 | 1288.25 | nM | IC50 | J Med Chem (2005) 48: 5666-5674 [PMID:16134935] |
ChEMBL | In vitro antagonist activity against rat prostatic androgen receptor (AR) | F | 7.19 | pIC50 | 64 | nM | IC50 | J Med Chem (1986) 29: 2298-2315 [PMID:3783591] |
GtoPdb | - | - | 8.56 | pIC50 | - | - | - | Chem Res Toxicol (2003) 16: 1338-58 [PMID:14565775] |
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185] | ||||||||
ChEMBL | In silico binding affinity to human corticosteriod binding globulin | B | 4.76 | pKd | 4.76 | - | -Log Kdiss | J Med Chem (1997) 40: 3161-3172 [PMID:9379435] |
ChEMBL | Binding affinity to human CBG receptor (corticosteroid-binding globulins) | B | 5.76 | pKi | 1737.8 | nM | Ki | J Med Chem (2004) 47: 2732-2742 [PMID:15139751] |
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
ChEMBL | Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]AD | B | 7.46 | pKi | 35 | nM | Ki | Eur J Med Chem (2015) 105: 1-38 [PMID:26469743] |
ChEMBL | Binding affinity for aromatase cytochrome P45019A1 by analysis of Dixon plot | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (1994) 37: 2198-2205 [PMID:8035427] |
ChEMBL | Inhibition of aromatase in human placental microsomes using [1beta-3H]AD as substrate incubated for 20 mins in presence of NADPH | B | 6 | pIC50 | 1000 | nM | IC50 | Eur J Med Chem (2020) 208: 112845-112845 [PMID:33017749] |
ChEMBL | In vitro competitive inhibitory activity was measured on Cytochrome P450 19A1 of human placental microsomes | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1994) 37: 2198-2205 [PMID:8035427] |
ChEMBL | Inhibition of aromatase | B | 6.59 | pIC50 | >=260 | nM | IC50 | Bioorg Med Chem (2012) 20: 2603-2613 [PMID:22444875] |
Estradiol 17-beta-dehydrogenase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4234] [UniProtKB: P37058] | ||||||||
ChEMBL | Inhibitory concentration against type-3 17-beta-HSD expressed in HEK293 cells | B | 6.12 | pIC50 | 758 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 2533-2536 [PMID:11086723] |
ChEMBL | Ability to inhibit the Type-3 17-beta- hydroxysteroid dehydrogenase activity transfected in human embryonic kidney (HEK)-293 cells experiment 1 | B | 6.12 | pIC50 | 758 | nM | IC50 | J Med Chem (2002) 45: 640-653 [PMID:11806715] |
ChEMBL | Inhibition of type-3 17 beta-hydroxysteroid dehydrogenase expressed in HEK293 cells at 37 degree C pH7.4 | B | 6.12 | pIC50 | 758 | nM | IC50 | J Med Chem (2005) 48: 5257-5268 [PMID:16078844] |
ChEMBL | Ability to inhibit the Type-3 17-beta- hydroxysteroid dehydrogenase activity transfected in human embryonic kidney (HEK)-293 cells experiment 2 | B | 6.19 | pIC50 | 650 | nM | IC50 | J Med Chem (2002) 45: 640-653 [PMID:11806715] |
ChEMBL | Ability to inhibit the Type-3 17-beta- hydroxysteroid dehydrogenase activity transfected in human embryonic kidney (HEK)-293 cells experiment 3 | B | 6.31 | pIC50 | 489 | nM | IC50 | J Med Chem (2002) 45: 640-653 [PMID:11806715] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278] | ||||||||
ChEMBL | Binding affinity towards human testosterone binding globulin. | B | 6.46 | pKd | 6.46 | - | -Log Kdiss | J Med Chem (1997) 40: 3161-3172 [PMID:9379435] |
ChEMBL | Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin | B | 7.46 | pKd | 34.67 | nM | Kd | J Med Chem (2008) 51: 2047-2056 [PMID:18330978] |
Testosterone 17-beta-dehydrogenase 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075158] [UniProtKB: O54939] | ||||||||
ChEMBL | Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate after 2 hrs | B | 6.77 | pIC50 | 169 | nM | IC50 | Bioorg Med Chem (2015) 23: 5433-5451 [PMID:26277760] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]