dioctanoylglycerol pyrophosphate [Ligand Id: 2916] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL191055
  • LPA1 receptor/Lysophosphatidic acid receptor Edg-2 in Human [ChEMBL: CHEMBL3819] [GtoPdb: 272] [UniProtKB: Q92633]
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  • LPA3 receptor/Lysophosphatidic acid receptor Edg-7 in Human [ChEMBL: CHEMBL3250] [GtoPdb: 274] [UniProtKB: Q9UBY5]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
LPA1 receptor/Lysophosphatidic acid receptor Edg-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3819] [GtoPdb: 272] [UniProtKB: Q92633]
GtoPdb - - 5.18 pKi 6600 nM Ki Curr Med Chem (2008) 15: 2122-31 [PMID:18781939];
Mol Pharmacol (2001) 60: 776-84 [PMID:11562440]
ChEMBL Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells B 5.37 pKi 4300 nM Ki J. Med. Chem. (2005) 48: 4919-4930 [PMID:16033271]
ChEMBL Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor F 5.26 pIC50 5500 nM IC50 J. Med. Chem. (2005) 48: 4919-4930 [PMID:16033271]
LPA3 receptor/Lysophosphatidic acid receptor Edg-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3250] [GtoPdb: 274] [UniProtKB: Q9UBY5]
ChEMBL Binding affinity for Lysophosphatidic acid receptor 3 expressed in RH7777 rat hepatoma cells B 6.69 pKi 202 nM Ki J. Med. Chem. (2005) 48: 4919-4930 [PMID:16033271]
GtoPdb - - 7 pKi 3330 nM Ki Mol Pharmacol (2003) 64: 994-1005 [PMID:14500756];
Mol Pharmacol (2001) 60: 776-84 [PMID:11562440]
ChEMBL Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA3 receptor F 6.34 pIC50 454 nM IC50 J. Med. Chem. (2005) 48: 4919-4930 [PMID:16033271]
GtoPdb - - 6.97 pIC50 106 nM IC50 Mol Pharmacol (2001) 60: 776-84 [PMID:11562440]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]