cromoglicic acid   Click here for help

GtoPdb Ligand ID: 7608

Synonyms: cromoglycate | cromolyn | cromolyn sodium | FPL-670 | Intal® | Opticrom® | sodium cromoglicate
Approved drug Immunopharmacology Ligand
cromoglicic acid is an approved drug (FDA (1984))
Compound class: Synthetic organic
Comment: Cromoglicic acid (cromolyn) is regarded as a mast cell stabilising drug, although its exact mechanism of action appears to be much more complicated.
Recent reports suggest that cromolyn inhibits glycogen synthase kinase 3β and may therefore have potential to treat diabetes and obesity [3] and may prove effective in treating insulin-induced lipoatrophy [4]. It also has reported potential anti-fibrotic action through agonism of GPR35 [1,5].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 173.71
Molecular weight 468.07
XLogP 3.48
No. Lipinski's rules broken 0
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Canonical SMILES OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O
Isomeric SMILES OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O
InChI InChI=1S/C23H16O11/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1984))
IUPAC Name Click here for help
5-[3-(2-carboxy-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
2427 cromoglicic acid
Synonyms Click here for help
cromoglycate | cromolyn | cromolyn sodium | FPL-670 | Intal® | Opticrom® | sodium cromoglicate
Database Links Click here for help
Specialist databases
GPCRdb Ligand cromoglicic acid
Other databases
CAS Registry No. 16110-51-3
ChEMBL Ligand CHEMBL428880
DrugBank Ligand DB01003
DrugCentral Ligand 741
GtoPdb PubChem SID 223365943
PubChem CID 2882
Search Google for chemical match using the InChIKey IMZMKUWMOSJXDT-UHFFFAOYSA-N
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UniChem Compound Search for chemical match using the InChIKey IMZMKUWMOSJXDT-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey IMZMKUWMOSJXDT-UHFFFAOYSA-N
Wikipedia Cromoglicic acid