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Synonyms: cromoglycate | cromolyn | cromolyn sodium | FPL-670 | Intal® | Opticrom® | sodium cromoglicate
cromoglicic acid is an approved drug (FDA (1984))
Compound class: Synthetic organic
Comment: Cromoglicic acid (cromolyn) is regarded as a mast cell stabilising drug, although its exact mechanism of action appears to be much more complicated.
Recent reports suggest that cromolyn inhibits glycogen synthase kinase 3β and may therefore have potential to treat diabetes and obesity  and may prove effective in treating insulin-induced lipoatrophy . It also has reported potential anti-fibrotic action through agonism of GPR35 [1,4].
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: cromoglicic acid
|Cromoglicic acid (cromolyn) is included in GToImmuPdb as it is a mast cell stabiliser that is used to treat various inflammatory conditions. It has a complex mechanism of action that likely involves modulation of several molecular targets (polypharmacology).|
|Mast cell stabiliser used to treat asthma.|
||Mast cell stabiliser used to treat allergic conjunctivitis.|
||Mast cell stabiliser used to treat mastocytosis.|