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Synonyms: cromoglycate | cromolyn | cromolyn sodium | FPL-670 | Intal® | Opticrom® | sodium cromoglicate
cromoglicic acid is an approved drug (FDA (1984))
Compound class: Synthetic organic
Comment: Cromoglicic acid (cromolyn) is regarded as a mast cell stabilising drug, although its exact mechanism of action appears to be much more complicated.
Recent reports suggest that cromolyn inhibits glycogen synthase kinase 3β and may therefore have potential to treat diabetes and obesity  and may prove effective in treating insulin-induced lipoatrophy . It also has reported potential anti-fibrotic action through agonism of GPR35 [1,4].
View more information in the IUPHAR Pharmacology Education Project: cromoglicic acid
|No information available.|
|Summary of Clinical Use|
|Cromoglicic acid is available in different formulations; nasal spray is used to treat allergic rhinitis, nebulizer solution to treat asthma, eye drops to treat allergic conjunctivitis and an oral form to treat mastocytosis, dermatographic urticaria and ulcerative colitis. Clinical use in asthma has largely been replaced by the more convenient leukotriene receptor antagonists.|
|Mechanism Of Action and Pharmacodynamic Effects|
|Cromoglicic acid is considered to predominantly stabilise mast cells and inhibit their degranulation. This action supresses the release of histamine and tryptase, thus reducing the synthesis of pro-inflammatory prostaglandins and leukotrienes. The drug also inhibits the activity of other types of inflammatory cells (eg eosinophils, neutrophils, macrophages, monocytes, and platelets) which are associated with asthma. As mast cell stabilisation is not sufficient on its own to explain the anti-asthmatic activity of this chromone type drug, other as yet incompletely resolved mechanisms must be involved.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)