arachidonylcyclopropylamide [Ligand Id: 739] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL418353
  • CB1 receptor/Cannabinoid CB1 receptor in Rat [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272]
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  • CB2 receptor/Cannabinoid CB2 receptor in Mouse [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936]
  • CB2 receptor/Cannabinoid CB2 receptor in Rat [ChEMBL: CHEMBL2470] [GtoPdb: 57] [UniProtKB: Q9QZN9]
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  • GPR18 in Human [GtoPdb: 89] [UniProtKB: Q14330]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272]
ChEMBL Binding affinity towards rat brain cannabinoid receptor 1 in the presence of PMSF upon incubation for 15 min at 4 degree C in pH 7.4 using [3H]CP-55940 B 8.57 pKi 2.7 nM Ki J. Med. Chem. (2005) 48: 6423-6429 [PMID:16190768]
ChEMBL Displacement of [3H]-CP55940 from CB1 receptor of rat cerebellar membranes by liquid scintillation counting in presence of serine protease inhibitor PMSF B 8.66 pKi 2.2 nM Ki J. Med. Chem. (2013) 56: 8224-8256 [PMID:23865723]
GtoPdb - - 8.7 pKi - - - J. Pharmacol. Exp. Ther. (1999) 289: 1427-33 [PMID:10336536]
ChEMBL Displacement of [35S]GTP-gamma-S from rat cerebellar CB1 receptor F 6.4 pEC50 398.11 nM EC50 J. Med. Chem. (2006) 49: 554-566 [PMID:16420041]
CB2 receptor/Cannabinoid CB2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936]
ChEMBL Binding affinity towards mouse spleen cannabinoid receptor 2 in the presence of PMSF upon incubation for 15 min at 4 degree C in pH 7.4 using [3H]CP-55940 B 6.8 pKi 157 nM Ki J. Med. Chem. (2005) 48: 6423-6429 [PMID:16190768]
CB2 receptor/Cannabinoid CB2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2470] [GtoPdb: 57] [UniProtKB: Q9QZN9]
ChEMBL Displacement of [3H]-CP55940 from CB2 receptor of rat spleen membranes by liquid scintillation counting in presence of serine protease inhibitor PMSF B 6.15 pKi 715 nM Ki J. Med. Chem. (2013) 56: 8224-8256 [PMID:23865723]
GPR18 in Human [GtoPdb: 89] [UniProtKB: Q14330]
GtoPdb - - 4.87 pEC50 13500 nM EC50 Br. J. Pharmacol. (2012) 165: 2414-24 [PMID:21595653]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]