arachidonylcyclopropylamide [Ligand Id: 739] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL418353 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] | ||||||||
| ChEMBL | Binding affinity towards rat brain cannabinoid receptor 1 in the presence of PMSF upon incubation for 15 min at 4 degree C in pH 7.4 using [3H]CP-55940 | B | 8.57 | pKi | 2.7 | nM | Ki | J Med Chem (2005) 48: 6423-6429 [PMID:16190768] |
| ChEMBL | Displacement of [3H]-CP55940 from CB1 receptor of rat cerebellar membranes by liquid scintillation counting in presence of serine protease inhibitor PMSF | B | 8.66 | pKi | 2.2 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| GtoPdb | - | - | 8.7 | pKi | - | - | - | J Pharmacol Exp Ther (1999) 289: 1427-33 [PMID:10336536] |
| ChEMBL | Displacement of [35S]GTP-gamma-S from rat cerebellar CB1 receptor | F | 6.4 | pEC50 | 398.11 | nM | EC50 | J Med Chem (2006) 49: 554-566 [PMID:16420041] |
| CB2 receptor/Cannabinoid CB2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936] | ||||||||
| ChEMBL | Binding affinity towards mouse spleen cannabinoid receptor 2 in the presence of PMSF upon incubation for 15 min at 4 degree C in pH 7.4 using [3H]CP-55940 | B | 6.8 | pKi | 157 | nM | Ki | J Med Chem (2005) 48: 6423-6429 [PMID:16190768] |
| CB2 receptor/Cannabinoid CB2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2470] [GtoPdb: 57] [UniProtKB: Q9QZN9] | ||||||||
| ChEMBL | Displacement of [3H]-CP55940 from CB2 receptor of rat spleen membranes by liquid scintillation counting in presence of serine protease inhibitor PMSF | B | 6.15 | pKi | 715 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| GPR18 in Human [GtoPdb: 89] [UniProtKB: Q14330] | ||||||||
| GtoPdb | - | - | 4.87 | pEC50 | 13500 | nM | EC50 | Br J Pharmacol (2012) 165: 2414-24 [PMID:21595653] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
