L779450 [Ligand Id: 9129] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL373011 (L-779450) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
| ChEMBL | Binding affinity at bRaf kinase in fluorescent ligand displacement assay | B | 8.62 | pKd | 2.4 | nM | Kd | Bioorg Med Chem Lett (2006) 16: 378-381 [PMID:16260133] |
| ChEMBL | Binding affinity to B-Raf by fluorescene ligand binding assay | B | 8.62 | pKd | 2.4 | nM | Kd | Bioorg Med Chem Lett (2008) 18: 4373-4376 [PMID:18621524] |
| GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 378-81 [PMID:16260133] |
| ChEMBL | Inhibition bRaf kinase activity | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 378-381 [PMID:16260133] |
| ChEMBL | Inhibition of B-Raf V600E mutant | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1248-1252 [PMID:21211972] |
| Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| GtoPdb | - | - | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2346-50 [PMID:18346893] |
| ChEMBL | Inhibition of Raf1 kinase | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2346-2350 [PMID:18346893] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
