talampanel   Click here for help

GtoPdb Ligand ID: 8279

Synonyms: GYKI 537773 | LY-300164 | LY300164
Compound class: Synthetic organic
Comment: Talampanel is a non-competitive antagonist of the AMPA receptors, a family of ionotropic glutamate receptors of the central nervous system. The compound shows some selectivity for GluA1 and GluA2 over GluA3 and GluA4 [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 77.15
Molecular weight 337.14
XLogP 3.01
No. Lipinski's rules broken 0
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Canonical SMILES Nc1ccc(cc1)C1=NN(C(=O)C)C(Cc2c1cc1OCOc1c2)C
Isomeric SMILES Nc1ccc(cc1)C1=NN(C(=O)C)[C@@H](Cc2c1cc1OCOc1c2)C
InChI InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
7820 talampanel
Synonyms Click here for help
GYKI 537773 | LY-300164 | LY300164
Database Links Click here for help
CAS Registry No. 161832-65-1
ChEMBL Ligand CHEMBL61872
DrugBank Ligand DB04982
GtoPdb PubChem SID 252166491
PubChem CID 164509
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Wikipedia Talampanel

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Cat. No. 5032