talampanel   Click here for help

GtoPdb Ligand ID: 8279

Synonyms: GYKI 537773 | LY-300164 | LY300164
Compound class: Synthetic organic
Comment: Talampanel is a non-competitive antagonist of the AMPA receptors, a family of ionotropic glutamate receptors of the central nervous system. The compound shows some selectivity for GluA1 and GluA2 over GluA3 and GluA4 [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 77.15
Molecular weight 337.14
XLogP 3.01
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES Nc1ccc(cc1)C1=NN(C(=O)C)C(Cc2c1cc1OCOc1c2)C
Isomeric SMILES Nc1ccc(cc1)C1=NN(C(=O)C)[C@@H](Cc2c1cc1OCOc1c2)C
InChI InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1
InChI Key JACAAXNEHGBPOQ-LLVKDONJSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
International Nonproprietary Names Click here for help
INN number INN
7820 talampanel
Synonyms Click here for help
GYKI 537773 | LY-300164 | LY300164
Database Links Click here for help
CAS Registry No. 161832-65-1
ChEMBL Ligand CHEMBL61872
DrugBank Ligand DB04982
GtoPdb PubChem SID 252166491
PubChem CID 164509
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Tocris
Talampanel
Cat. No. 5032