MMPIP [Ligand Id: 3341] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL593489
  • mGlu7 receptor/Metabotropic glutamate receptor 7 in Rat [ChEMBL: CHEMBL3879] [GtoPdb: 295] [UniProtKB: P35400]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu7 receptor/Metabotropic glutamate receptor 7 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879] [GtoPdb: 295] [UniProtKB: P35400]
ChEMBL Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR F 7.59 pIC50 26 nM IC50 Bioorg Med Chem Lett (2010) 20: 726-729 [PMID:20005101]
ChEMBL Allosteric antagonist activity at rat mGlu7 receptor expressed in CHO cell co-expressing Galpha15 (unknown origin) assessed as reduction in L-AP4-induced intracellular Ca2+ mobilization F 7.59 pIC50 26 nM IC50 Medchemcomm (2019) 10: 193-199 [PMID:30881607]
GtoPdb - - 7.6 pIC50 25 nM IC50 J Pharmacol Exp Ther (2007) 323: 147-56 [PMID:17609420];
Mol Pharmacol (2010) 77: 459-68 [PMID:20026717]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]