ChEMBL ligand: CHEMBL593489
mGlu7 receptor/Metabotropic glutamate receptor 7 in Rat [ChEMBL: CHEMBL3879] [GtoPdb: 295] [UniProtKB: P35400] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mGlu7 receptor/Metabotropic glutamate receptor 7 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879] [GtoPdb: 295] [UniProtKB: P35400]
ChEMBL	Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR	F	7.59	pIC50	26	nM	IC50	Bioorg Med Chem Lett (2010) 20: 726-729 [PMID:20005101]
ChEMBL	Allosteric antagonist activity at rat mGlu7 receptor expressed in CHO cell co-expressing Galpha15 (unknown origin) assessed as reduction in L-AP4-induced intracellular Ca2+ mobilization	F	7.59	pIC50	26	nM	IC50	Medchemcomm (2019) 10: 193-199 [PMID:30881607]
GtoPdb	-	-	7.6	pIC50	25	nM	IC50	J Pharmacol Exp Ther (2007) 323: 147-56 [PMID:17609420]; Mol Pharmacol (2010) 77: 459-68 [PMID:20026717]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]