MMPIP [Ligand Id: 3341] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL593489
  • mGlu7 receptor/Metabotropic glutamate receptor 7 in Rat [ChEMBL: CHEMBL3879] [GtoPdb: 295] [UniProtKB: P35400]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu7 receptor/Metabotropic glutamate receptor 7 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879] [GtoPdb: 295] [UniProtKB: P35400]
ChEMBL Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR F 7.59 pIC50 26 nM IC50 Bioorg Med Chem Lett (2010) 20: 726-729 [PMID:20005101]
ChEMBL Allosteric antagonist activity at rat mGlu7 receptor expressed in CHO cell co-expressing Galpha15 (unknown origin) assessed as reduction in L-AP4-induced intracellular Ca2+ mobilization F 7.59 pIC50 26 nM IC50 Medchemcomm (2019) 10: 193-199 [PMID:30881607]
GtoPdb - - 7.6 pIC50 25 nM IC50 J Pharmacol Exp Ther (2007) 323: 147-56 [PMID:17609420];
Mol Pharmacol (2010) 77: 459-68 [PMID:20026717]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]