ChEMBL ligand: CHEMBL1230001
retinol binding protein 4/Plasma retinol-binding protein in Human [ChEMBL: CHEMBL3100] [GtoPdb: 2549] [UniProtKB: P02753] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
retinol binding protein 4/Plasma retinol-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3100] [GtoPdb: 2549] [UniProtKB: P02753]
ChEMBL	Inhibition of retinol-induced interaction of bacterially expressed MBP-tagged RBP4 (unknown origin) with Eu3+ cryptate labeled TTR by HTRF assay	B	6.91	pIC50	122	nM	IC50	J Med Chem (2015) 58: 5863-5888 [PMID:26181715]
ChEMBL	Displacement of [3H]-retinol from human recombinant RBP4 by scintillation proximity assay	B	7.05	pIC50	89	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2885-2891 [PMID:24835984]
ChEMBL	Competitive displacement of 3[H]retinol from biotinylated RBP4 (unknown origin) by surface plasmon resonance analysis	B	7.82	pIC50	15	nM	IC50	J Med Chem (2019) 62: 5470-5500 [PMID:31079449]
ChEMBL	Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay	B	7.82	pIC50	15	nM	IC50	J Med Chem (2015) 58: 5863-5888 [PMID:26181715]
ChEMBL	Displacement of [3H]retinol from biotinylated human RBP4 by scintillation proximity assay	B	7.83	pIC50	14.8	nM	IC50	J Med Chem (2014) 57: 7731-7757 [PMID:25210858]
GtoPdb	Measured using a FRET assay to monitor human RBP4–transthyretin interaction.	-	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2885-91 [PMID:24835984]
ChEMBL	Inhibition of human recombinant RBP4-transthyretin interaction by FRET analysis	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2885-2891 [PMID:24835984]
ChEMBL	Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced protein/transthyretin interaction by HTRF assay	B	9.81	pIC50	0.15	nM	IC50	J Med Chem (2014) 57: 7731-7757 [PMID:25210858]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]