Synonyms: compound 10b [PMID 19006286] | NBI-56418 | NBI56418 | Orilissa®
elagolix is an approved drug (FDA (2018))
Compound class:
Synthetic organic
Comment: Elagolix is a non-peptide gonadotrophin receptor (GnRHR) antagonist [1]. As of July 2018, it is the first and only FDA-approved oral GnRH antagonist available for the treatment of moderate to severe endometriosis pain.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (FDA (2018)) |
IUPAC Name |
4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid |
International Nonproprietary Names | |
INN number | INN |
8983 | elagolix |
Synonyms |
compound 10b [PMID 19006286] | NBI-56418 | NBI56418 | Orilissa® |
Database Links | |
Specialist databases | |
GPCRdb Ligand | elagolix |
Other databases | |
CAS Registry No. | 834153-87-6 |
ChEMBL Ligand | CHEMBL1208155 |
DrugCentral Ligand | 5293 |
GtoPdb PubChem SID | 252166574 |
PubChem CID | 11250647 |
RCSB PDB Ligand | F5O |
Search Google for chemical match using the InChIKey | HEAUOKZIVMZVQL-VWLOTQADSA-N |
Search Google for chemicals with the same backbone | HEAUOKZIVMZVQL |
Search PubMed clinical trials | elagolix |
Search PubMed titles | elagolix |
Search PubMed titles/abstracts | elagolix |
UniChem Compound Search for chemical match using the InChIKey | HEAUOKZIVMZVQL-VWLOTQADSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | HEAUOKZIVMZVQL-VWLOTQADSA-N |