Synonyms: ETX-0462 | VMM
Compound class:
Synthetic organic
Comment: ETX0462 is a diazabicyclooctane molecule that represents a new class of antibacterial. It is a β-lactamase inhibitor that also acts as a single agent antibacterial through its capacity to inhibit penicillin-binding proteins [1]. It has a broad-spectrum of activity (in vitro and in vivo) against Gram-negative bacteria including virulent and antibacterial resistant ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), Stenotrophomonas maltophilia and bacterial agents that might be used as biological weapons. Further optimisation of ETX0462 is required to improve its permeability across bacterial outer membranes and increase its biochemical potency.
The crystal structure of ETX0462 bound to P. aeruginosa penicillin binding protein 3 (PBP3) has been resolved at a resolution of 2.2 Å (PDB ID: 7JWL) [1]. |
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Classification | |
Compound class | Synthetic organic |
Synonyms |
ETX-0462 | VMM |
Database Links | |
Specialist databases | |
Antibiotic DB | ETX0462 |
Other databases | |
GtoPdb PubChem SID | 458923788 |
PubChem CID | 155920149 |
RCSB PDB Ligand | VMM |
Search Google for chemical match using the InChIKey | TVYRNFNEBLNAMJ-XPUUQOCRSA-N |
Search Google for chemicals with the same backbone | TVYRNFNEBLNAMJ |
UniChem Compound Search for chemical match using the InChIKey | TVYRNFNEBLNAMJ-XPUUQOCRSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | TVYRNFNEBLNAMJ-XPUUQOCRSA-N |