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ChEMBL ligand: CHEMBL456341 (Ajulemic acid, Ajulemic Acid, CPL7075, CPL-7075, CT-3, HU-239, IP-751, JBT-101, Lenabasum, Resunab) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
GtoPdb | - | - | 7.49 | pKi | 32.3 | nM | Ki |
J Med Chem (2013) 56: 8224-56 [PMID:23865723]; J Med Chem (1997) 40: 3228-33 [PMID:9379442] |
ChEMBL | Binding affinity to human CB1 receptor | B | 7.49 | pKi | 32.3 | nM | Ki | J. Med. Chem. (2013) 56: 8224-8256 [PMID:23865723] |
ChEMBL | Binding affinity to CB1 receptor (unknown origin) | B | 8.24 | pKi | 5.7 | nM | Ki | Bioorg. Med. Chem. (2014) 22: 2830-2843 [PMID:24731541] |
ChEMBL | Agonist activity at CB1 receptor (unknown origin) assessed as cAMP production | F | 6.03 | pEC50 | 927 | nM | EC50 | J. Med. Chem. (2013) 56: 8224-8256 [PMID:23865723] |
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
ChEMBL | Binding affinity to human CB2 receptor | B | 6.77 | pKi | 170.5 | nM | Ki | J. Med. Chem. (2013) 56: 8224-8256 [PMID:23865723] |
GtoPdb | - | - | 6.77 | pKi | 170 | nM | Ki |
J Med Chem (2013) 56: 8224-56 [PMID:23865723]; J Med Chem (1997) 40: 3228-33 [PMID:9379442] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]