retinol [Ligand Id: 4053] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL986 (Retinol palmitate, Retinol, Vitamin A Solubilized, NSC-122759, Vitamin A 1, Retinol (vit a), Ro-a-vit, Arovit, Vitamin a, Oleovitamin a, Aquasol a, Vitamin A, Retinol acetate, Vitamin a oil, Nepalm)
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  • retinol binding protein 4/Plasma retinol-binding protein in Human [ChEMBL: CHEMBL3100] [GtoPdb: 2549] [UniProtKB: P02753]
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  • Testicular receptor 4 in Human [GtoPdb: 614] [UniProtKB: P49116]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-lactoglobulin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075053] [UniProtKB: P02754]
ChEMBL Binding affinity to bovine beta-lactoglobulins by fluorescence spectroscopy B 7.44 pKd 36 nM Kd J. Med. Chem. (2010) 53: 514-518 [PMID:19938842]
retinol binding protein 4/Plasma retinol-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3100] [GtoPdb: 2549] [UniProtKB: P02753]
ChEMBL Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis B 6.74 pKd 182 nM Kd J. Med. Chem. (2011) 54: 4378-4387 [PMID:21591606]
Testicular receptor 4 in Human [GtoPdb: 614] [UniProtKB: P49116]
GtoPdb - - 4.71 pEC50 19400 nM EC50 J Biol Chem (2011) 286: 2877-85 [PMID:21068381]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]