retinol [Ligand Id: 4053] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL986 (Aquasol a, Arovit, Nepalm, NSC-122759, Oleovitamin a, Retinol, Retinol acetate, Retinol palmitate, Retinol (vit a), Ro-a-vit, Vitamin a, Vitamin A, Vitamin A 1, Vitamin a oil, Vitamin A Solubilized)
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  • retinol binding protein 4/Plasma retinol-binding protein in Human [ChEMBL: CHEMBL3100] [GtoPdb: 2549] [UniProtKB: P02753]
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  • Testicular receptor 4 in Human [GtoPdb: 614] [UniProtKB: P49116]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840]
ChEMBL Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay B 6.72 pIC50 190 nM IC50 Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Inhibition of amyloid beta (1 to 40) (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay B 6.74 pIC50 180 nM IC50 Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
Beta-lactoglobulin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075053] [UniProtKB: P02754]
ChEMBL Binding affinity to bovine beta-lactoglobulins by fluorescence spectroscopy B 7.44 pKd 36 nM Kd J Med Chem (2010) 53: 514-518 [PMID:19938842]
retinol binding protein 4/Plasma retinol-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3100] [GtoPdb: 2549] [UniProtKB: P02753]
ChEMBL Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis B 6.74 pKd 182 nM Kd J Med Chem (2011) 54: 4378-4387 [PMID:21591606]
Testicular receptor 4 in Human [GtoPdb: 614] [UniProtKB: P49116]
GtoPdb - - 4.71 pEC50 19400 nM EC50 J Biol Chem (2011) 286: 2877-85 [PMID:21068381]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]