AZD7687 [Ligand Id: 7827] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2178953 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acyl coenzyme A:cholesterol acyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2782] [UniProtKB: P35610] | ||||||||
| ChEMBL | Inhibition of human ACAT1 by liquid scintillography | B | 4.47 | pIC50 | 34000 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| Acyl coenzyme A:cholesterol acyltransferase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4465] [UniProtKB: O75908] | ||||||||
| ChEMBL | Inhibition of human ACAT2 by liquid scintillography | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| ChEMBL | Inhibition of FAAH | B | 5.43 | pIC50 | 3700 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6009] [GtoPdb: 2821] [UniProtKB: O75907] | ||||||||
| ChEMBL | Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillography | B | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| GtoPdb | Measured using purified human DGAT1 | - | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2012) 55: 10610-29 [PMID:23116186] |
| ChEMBL | Inhibition of DGAT1 in human liver microsomes | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| ChEMBL | Inhibition of DGAT1 in human HuTu80 cells | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| ChEMBL | Inhibition of DGAT1 in human adipose tissue assessed as reduction in triacylglycerol synthesis | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075284] [GtoPdb: 2821] [UniProtKB: Q9Z2A7] | ||||||||
| ChEMBL | Inhibition of DGAT1 in mouse liver microsomes | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6129] [GtoPdb: 2821] [UniProtKB: Q9ERM3] | ||||||||
| ChEMBL | Inhibition of DGAT1 in rat liver microsomes | B | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| ChEMBL | Inhibition of DGAT1 in rat adipose tissue assessed as reduction in triacylglycerol synthesis | B | 7.05 | pIC50 | 90 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| diacylglycerol O-acyltransferase 2/Diacylglycerol O-acyltransferase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5853] [GtoPdb: 3211] [UniProtKB: Q96PD7] | ||||||||
| ChEMBL | Inhibition of recombinant FLAG-tagged human DGAT2 expressed in SF9 cells after 1 hr by TopCount assay | B | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2020) 63: 5031-5073 [PMID:31930920] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG | B | 4.49 | pIC50 | >32000 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| ChEMBL | Inhibition of muscarinic M2 receptor | B | 4.09 | pIC50 | 80500 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| O-acyltransferase in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176848] [UniProtKB: A0A8I3N393] | ||||||||
| ChEMBL | Inhibition of DGAT1 in dog liver microsomes | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
| phosphodiesterase 10A/Phosphodiesterase 10A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233] | ||||||||
| ChEMBL | Inhibition of PDE10A1 receptor | B | 5.26 | pIC50 | 5500 | nM | IC50 | J Med Chem (2012) 55: 10610-10629 [PMID:23116186] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
