ChEMBL ligand: CHEMBL461415
SHP/Nuclear receptor subfamily 0 group B member 2 in Human [ChEMBL: CHEMBL5603] [GtoPdb: 636] [UniProtKB: Q15466] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
SHP/Nuclear receptor subfamily 0 group B member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5603] [GtoPdb: 636] [UniProtKB: Q15466]
GtoPdb	-	-	6.3	pIC50	500	nM	IC50	J Med Chem (2008) 51: 5650-62 [PMID:18759424]
ChEMBL	Displacement of [5,5'-3H2]AHPN from human recombinant GST-SHP by liquid scintillation counting relative to 3-Cl-AHPC	B	6.3	pIC50	500	nM	IC50	J Med Chem (2008) 51: 5650-5662 [PMID:18759424]
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124]
ChEMBL	Inhibition of SHP2 overexpressed in human KG1 cells	B	5.64	pIC50	2270	nM	IC50	J Med Chem (2008) 51: 5650-5662 [PMID:18759424]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]