compound 19 [PMID: 8831774] [Ligand Id: 8569] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL130506 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| calpain 1/Calpain 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3891] [GtoPdb: 2336] [UniProtKB: P07384] | ||||||||
| ChEMBL | Inhibition of the cysteine protease human Calpain 1 | B | 5.96 | pKi | 1100 | nM | Ki | J Med Chem (1996) 39: 4089-4098 [PMID:8831774] |
| calpain 2/Calpain 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2382] [GtoPdb: 2337] [UniProtKB: P17655] | ||||||||
| ChEMBL | Compound was evaluated for the inhibition of Cysteine protease Calpain 2 | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (1996) 39: 4089-4098 [PMID:8831774] |
| GtoPdb | - | - | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1996) 39: 4089-98 [PMID:8831774] |
| cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
| ChEMBL | Inhibition of human cathepsin B | B | 6.43 | pKi | 370 | nM | Ki | J Med Chem (1996) 39: 4089-4098 [PMID:8831774] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
