ChEMBL ligand: CHEMBL178707 (T-226296)
MCH1 receptor/Melanin-concentrating hormone receptor 1 in Human [ChEMBL: CHEMBL344] [GtoPdb: 280] [UniProtKB: Q99705] MCH1 receptor/Melanin-concentrating hormone receptor 1 in Rat [ChEMBL: CHEMBL1075228] [GtoPdb: 280] [UniProtKB: P97639] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MCH1 receptor/Melanin-concentrating hormone receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL344] [GtoPdb: 280] [UniProtKB: Q99705]
ChEMBL	Displacement of [125I][Phe13, Tyr19]MCH from human recombinant MCHR1 expressed in CHO cells	B	7.42	pKi	38	nM	Ki	Bioorg Med Chem Lett (2007) 17: 3754-3759 [PMID:17448659]
ChEMBL	Displacement of [125I]MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cells	B	8.26	pKi	5.5	nM	Ki	Bioorg Med Chem Lett (2005) 15: 999-1004 [PMID:15686900]
ChEMBL	Concentration required to inhibit 50% of melanin-concentrating hormone induced [Ca2+] flux in IMR-32 cells measured by using a fluorometric imaging plate reader	F	6.06	pIC50	872	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4879-4882 [PMID:15341943]
ChEMBL	Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes	B	7.07	pIC50	85	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4879-4882 [PMID:15341943]
ChEMBL	Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation counting	F	7.37	pIC50	43	nM	IC50	Bioorg Med Chem (2011) 19: 5539-5552 [PMID:21856163]
ChEMBL	Antagonist activity at MCH1R by [35S]GTPgammaS binding assay	F	7.72	pIC50	19	nM	IC50	J Med Chem (2009) 52: 2076-2089 [PMID:19290642]
ChEMBL	Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem (2011) 19: 5539-5552 [PMID:21856163]
ChEMBL	Displacement of [125I]-MCH(4-19) from human MCHR1 expressed in CHO cells	B	8.26	pIC50	5.5	nM	IC50	Bioorg Med Chem (2011) 19: 6261-6273 [PMID:21975069]
ChEMBL	Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells	B	8.26	pIC50	5.5	nM	IC50	J Med Chem (2004) 47: 3962-3971 [PMID:15267235]
ChEMBL	Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay	F	8.26	pIC50	5.5	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6166-6171 [PMID:19773162]
ChEMBL	Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay	B	8.26	pIC50	5.5	nM	IC50	Bioorg Med Chem (2011) 19: 883-893 [PMID:21190859]
GtoPdb	-	-	8.3	pIC50	5.01	nM	IC50	Eur J Pharmacol (2002) 438: 129-35 [PMID:11909603]
MCH1 receptor/Melanin-concentrating hormone receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075228] [GtoPdb: 280] [UniProtKB: P97639]
ChEMBL	Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting	B	7.62	pIC50	24	nM	IC50	Bioorg Med Chem (2011) 19: 5539-5552 [PMID:21856163]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]