[3H]banyu (I) [Ligand Id: 795] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL20921
  • CCR1/C-C chemokine receptor type 1 in Human [ChEMBL: CHEMBL2413] [GtoPdb: 58] [UniProtKB: P32246]
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  • CCR3/C-C chemokine receptor type 3 in Human [ChEMBL: CHEMBL3473] [GtoPdb: 60] [UniProtKB: P51677]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCR1/C-C chemokine receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2413] [GtoPdb: 58] [UniProtKB: P32246]
ChEMBL Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells B 5.72 pIC50 1900 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 1219-1223 [PMID:11354381]
CCR3/C-C chemokine receptor type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3473] [GtoPdb: 60] [UniProtKB: P51677]
GtoPdb - - 8.3 pKd - - - Eur. J. Pharmacol. (2002) 456: 1-10 [PMID:12450563]
ChEMBL Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand B 8.64 pIC50 2.3 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 3597-3600 [PMID:14505678]
ChEMBL Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells B 8.64 pIC50 2.3 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 1219-1223 [PMID:11354381]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]