[3H]banyu (I) [Ligand Id: 795] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL20921
  • CCR1/C-C chemokine receptor type 1 in Human [ChEMBL: CHEMBL2413] [GtoPdb: 58] [UniProtKB: P32246]
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  • CCR3/C-C chemokine receptor type 3 in Human [ChEMBL: CHEMBL3473] [GtoPdb: 60] [UniProtKB: P51677]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCR1/C-C chemokine receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2413] [GtoPdb: 58] [UniProtKB: P32246]
ChEMBL Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells B 5.72 pIC50 1900 nM IC50 Bioorg Med Chem Lett (2001) 11: 1219-1223 [PMID:11354381]
CCR3/C-C chemokine receptor type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3473] [GtoPdb: 60] [UniProtKB: P51677]
GtoPdb - - 8.3 pKd - - - Eur J Pharmacol (2002) 456: 1-10 [PMID:12450563]
ChEMBL Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand B 8.64 pIC50 2.3 nM IC50 Bioorg Med Chem Lett (2003) 13: 3597-3600 [PMID:14505678]
ChEMBL Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells B 8.64 pIC50 2.3 nM IC50 Bioorg Med Chem Lett (2001) 11: 1219-1223 [PMID:11354381]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]