capuramycin [Ligand Id: 13471] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL96695 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Phospho-N-acetylmuramoyl-pentapeptide-transferase in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770035] [UniProtKB: P0C1R8] | ||||||||
| ChEMBL | Inhibition of Staphylococcus aureus MraY assessed as reduction of dansylated lipid I formation using UDP-MurNAc-dansylpentapeptide as substrate incubated for 3 to 4 hrs by fluorescence based analysis | B | 6.48 | pIC50 | 330 | nM | IC50 | Bioorg Med Chem (2022) 73: 117011-117011 [PMID:36191548] |
| Phospho-N-acetylmuramoyl-pentapeptide-transferase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3957] [UniProtKB: P0A6W3] | ||||||||
| ChEMBL | Inhibitory activity against translocase I | B | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2829-2832 [PMID:14611838] |
| UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4739704] [UniProtKB: Q9H3H5] | ||||||||
| ChEMBL | Inhibition of human DPAGT1 expressed in HEK293 (Expi293) cells incubated for 2 hrs using UDP-GlcN-Cg-FITC and alpha-dihydroundecap-renyl phosphate by reversed-phase HPLC analysis | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2020) 63: 10855-10878 [PMID:32886511] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
