BPKDi [Ligand Id: 9370] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1214999 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Inhibition of beta-1 adrenoceptor | B | 5.08 | pIC50 | 8300 | nM | IC50 | J Med Chem (2010) 53: 5422-5438 [PMID:20684592] |
| protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] | ||||||||
| GtoPdb | In a biochemical enzyme assay. | - | 9 | pIC50 | 1 | nM | IC50 | FEBS Lett (2010) 584: 631-7 [PMID:20018189] |
| ChEMBL | Inhibition of PKD1 by TR-FRET assay | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2010) 53: 5422-5438 [PMID:20684592] |
| ChEMBL | Inhibition of PKD1 assessed as inhibition of HDAC5 neuclear export | B | 7.11 | pEC50 | 77 | nM | EC50 | J Med Chem (2010) 53: 5422-5438 [PMID:20684592] |
| protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] | ||||||||
| ChEMBL | Inhibition of PKD2 by TR-FRET assay | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2010) 53: 5422-5438 [PMID:20684592] |
| GtoPdb | In a biochemical enzyme assay. | - | 8.05 | pIC50 | 9 | nM | IC50 | FEBS Lett (2010) 584: 631-7 [PMID:20018189] |
| protein kinase D3 in Human [GtoPdb: 2174] [UniProtKB: O94806] | ||||||||
| GtoPdb | In a biochemical enzyme assay. | - | 9 | pIC50 | 1 | nM | IC50 | FEBS Lett (2010) 584: 631-7 [PMID:20018189] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
