ChEMBL ligand: CHEMBL1921847 (Aticaprant, Cerc-501, CERC-501, Jnj-67953964, JNJ-67953964-AAA, JSPA-0658, JSPA0658, Ly2456302, LY-2456302, LY2456302)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]diprenorphine from human opioid delta receptor expressed in HEK293 cells after 120 mins by scintillation counting	B	6.78	pKi	166	nM	Ki	J Med Chem (2011) 54: 8000-8012 [PMID:21958337]
GtoPdb	-	-	6.81	pKi	155	nM	Ki	Neuropharmacology (2014) 77: 131-44 [PMID:24071566]
ChEMBL	Binding affinity to human cloned DOR in presence of Na+/GDP	B	6.91	pKi	122	nM	Ki	J Med Chem (2013) 56: 2178-2195 [PMID:23360448]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting	B	9.02	pKi	0.95	nM	Ki	J Med Chem (2011) 54: 8000-8012 [PMID:21958337]
GtoPdb	-	-	9.09	pKi	0.81	nM	Ki	Neuropharmacology (2014) 77: 131-44 [PMID:24071566]
ChEMBL	Antagonist activity at kappa opioid receptor (unknown origin)	B	9.1	pKi	0.8	nM	Ki	Eur J Med Chem (2015) 90: 742-750 [PMID:25513968]
ChEMBL	Binding affinity to human cloned KOR in presence of Na+/GDP	B	9.22	pKi	0.6	nM	Ki	J Med Chem (2013) 56: 2178-2195 [PMID:23360448]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb	-	-	7.62	pKi	24	nM	Ki	Neuropharmacology (2014) 77: 131-44 [PMID:24071566]
ChEMBL	Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting	B	7.64	pKi	22.7	nM	Ki	J Med Chem (2011) 54: 8000-8012 [PMID:21958337]
ChEMBL	Binding affinity to human cloned MOR in presence of Na+/GDP	B	7.79	pKi	16.4	nM	Ki	J Med Chem (2013) 56: 2178-2195 [PMID:23360448]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]