aloisine A [Ligand Id: 5924] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL75680 (Aloisine A)
  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
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  • casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
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  • Cell division control protein 28 in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
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  • cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
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  • CFTR/Cystic fibrosis transmembrane conductance regulator in Human [ChEMBL: CHEMBL4051] [GtoPdb: 707] [UniProtKB: P13569]
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  • glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • mitogen-activated protein kinase 3/MAP kinase ERK1 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
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  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
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  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
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  • protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
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  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
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  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
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  • protein kinase C gamma/Protein kinase C gamma in Human [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
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  • protein kinase D1/Protein kinase C mu in Human [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
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  • protein kinase C zeta/Protein kinase C zeta in Human [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
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  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
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  • Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
ChEMBL Inhibition of Casein kinase II B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
ChEMBL Inhibition of CK1 B 4 pIC50 >=100000 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Inhibition of CK2 B 4 pIC50 >=100000 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
ChEMBL Inhibition of hemagglutininin-tagged Saccharomyces cerevisiae MNY629 Cdc28/Clb2 B 5.6 pIC50 2500 nM IC50 Bioorg. Med. Chem. (2009) 17: 5572-5582 [PMID:19596197]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067P06493P14635Q8WWL7]
GtoPdb CDK1 in association with cyclin B - 6.82 pIC50 150 nM IC50 J. Med. Chem. (2003) 46: 222-36 [PMID:12519061]
ChEMBL Inhibitory activity against cyclin-dependent kinase 1-cyclin B in starfish B 6.82 pIC50 150 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
ChEMBL Inhibition of CDK1/cyclinB B 6.82 pIC50 150 nM IC50 Trends Pharmacol. Sci. (2004) 25: 471-480 [PMID:15559249]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248P24941P78396]
GtoPdb CDK2 in association with cyclin A - 6.92 pIC50 120 nM IC50 J. Med. Chem. (2003) 46: 222-36 [PMID:12519061]
ChEMBL Inhibition of Cyclin-dependent kinase 2-cyclin A B 6.92 pIC50 120 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020P24864P24941]
ChEMBL Inhibition of Cyclin-dependent kinase 2-cyclin E B 6.4 pIC50 400 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
GtoPdb CDK2 in association with cyclin A - 6.92 pIC50 120 nM IC50 J. Med. Chem. (2003) 46: 222-36 [PMID:12519061]
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802P24385]
ChEMBL Inhibition of Cyclin-dependent kinase 4-cyclin D1 B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
ChEMBL Inhibitory activity against recombinant mammalian cyclin-dependent kinase 5 (p35 NCK5a) expressed in Escherichia coli B 6.7 pIC50 200 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
ChEMBL Inhibition of cyclin-dependent kinase 5/p25; range 0.16-0.2 B 6.7 pIC50 200 nM IC50 J. Med. Chem. (2005) 48: 671-679 [PMID:15689152]
ChEMBL Inhibition of GST-fused recombinant CDK5/p25 expressed in Escherichia coli after 30 mins by scintillation counting B 6.7 pIC50 200 nM IC50 Bioorg. Med. Chem. (2009) 17: 5572-5582 [PMID:19596197]
ChEMBL Inhibition of Cyclin-dependent kinase 5-p35nck5a B 6.8 pIC50 160 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
GtoPdb CDK5 p35 - 6.8 pIC50 160 nM IC50 J. Med. Chem. (2003) 46: 222-36 [PMID:12519061]
CFTR/Cystic fibrosis transmembrane conductance regulator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4051] [GtoPdb: 707] [UniProtKB: P13569]
ChEMBL Activity at human wild type CFTR expressed in CHO cells assessed as forskolin stimulated iodide flux B 6.82 pEC50 150 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Activity at human wild type CFTR expressed in Calu3 cells assessed as forskolin stimulated iodide flux B 6.85 pEC50 140 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Activity at human wild type CFTR expressed in F508del-CF1 cells assessed as forskolin stimulated iodide flux B 6.95 pEC50 111 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL Inhibition of GSK3alpha B 5.82 pIC50 1500 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb - - 6.3 pIC50 500 nM IC50 J. Med. Chem. (2003) 46: 222-36 [PMID:12519061]
ChEMBL Inhibition of Glycogen synthase kinase-3 alpha B 6.3 pIC50 500 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of Glycogen synthase kinase-3 beta B 5.82 pIC50 1500 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
ChEMBL Inhibition of GSK3-beta B 5.82 pIC50 1500 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Inhibition of glycogen synthase kinase-3 beta, purified from porcine brain or expressed in and purified from insect Sf9 cells B 6.19 pIC50 650 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
ChEMBL Inhibition of GSK3beta (unknown origin) B 6.19 pIC50 650 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 1532-1537 [PMID:24560539]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL Inhibition of Insulin receptor kinase B 4.22 pIC50 60000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
ChEMBL Inhibition of Mitogen-activated protein kinase 3 B 4.74 pIC50 18000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Inhibition of Mitogen-activated protein kinase 1 B 4.66 pIC50 22000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Inhibition of protein kinase C alpha B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
ChEMBL Inhibition of Protein kinase C beta B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
ChEMBL Inhibition of Protein kinase C beta B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL Inhibition of protein kinase C delta B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Inhibition of protein kinase C epsilon B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
ChEMBL Inhibition of Protein kinase C gamma B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
ChEMBL Inhibition of Protein kinase C mu B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
ChEMBL Inhibition of protein kinase C zeta B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL Inhibition of Protein kinase PIM-1 B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]
Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
ChEMBL Inhibition of RAF proto-oncogene serine/threonine-protein kinase (c-raf) B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2003) 46: 222-236 [PMID:12519061]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]