tanezumab   Click here for help

GtoPdb Ligand ID: 8415

Synonyms: PF-04383119 | PF04383119 | RN624
Compound class: Antibody
Comment: Tanezumab is an investigational monoclonal antibody targeting nerve growth factor (NGF). NGF is a neurotrophin that regulates the development and survival of a select population of neurons through the binding and activation of the neurotrophic receptor tyrosine kinase 1 (TrkA receptor). Elevated levels of NGF have been associated with painful pathologies including diabetic neuropathy, fibromyalgia and osteoarthritis, and cancer apin. Inhibition of NGF signalling has been explored for anti-pain potential.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. BLAST peptide sequence analysis reveals identical sequences are claimed in patent US7449616.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
8941 tanezumab
Synonyms Click here for help
PF-04383119 | PF04383119 | RN624
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 230
Other databases
GtoPdb PubChem SID 252166625
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Wikipedia Tanezumab