alfentanil [Ligand Id: 7108] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL634 (Afentanyl, Alfentanil, Alfentanyl, IDS-NA-014, R-39209, R-39209-)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL In vitro binding activity against opioid receptor kappa using [3H]EKC) as radioligand B 5 pIC50 >10000 nM IC50 J. Med. Chem. (1991) 34: 827-841 [PMID:1847432]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL Ability to displace [3H]naloxone from the Opioid receptor mu 1 isolated from the rat brain membranes. B 8.09 pKi 8.21 nM Ki J. Med. Chem. (1990) 33: 2876-2882 [PMID:2170652]
ChEMBL Displacement of [3H]DAMGO from rat brain mu opioid receptor incubated for 60 mins by microbeta scintillation counting method B 7.41 pIC50 38.9 nM IC50 MedChemComm (2019) 10: 1187-1191 [PMID:31391893]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL In vitro binding activity against opioid receptor mu using [3H]DAGO) as radioligand B 7.82 pIC50 15 nM IC50 J. Med. Chem. (1991) 34: 827-841 [PMID:1847432]
Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492]
ChEMBL Displacement of [3H]pentazocine from LAL/HA/BR guinea pig brain sigma1 receptor incubated for 90 mins by liquid scintillation counting method B 5 pIC50 >10000 nM IC50 MedChemComm (2019) 10: 1187-1191 [PMID:31391893]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]