alfentanil [Ligand Id: 7108] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL634 (Afentanyl, Alfentanil, Alfentanyl, IDS-NA-014, R-39209, R-39209-)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL In vitro binding activity against opioid receptor kappa using [3H]EKC) as radioligand B 5 pIC50 >10000 nM IC50 J Med Chem (1991) 34: 827-841 [PMID:1847432]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL Ability to displace [3H]naloxone from the Opioid receptor mu 1 isolated from the rat brain membranes. B 8.09 pKi 8.21 nM Ki J Med Chem (1990) 33: 2876-2882 [PMID:2170652]
ChEMBL Displacement of [3H]DAMGO from rat brain mu opioid receptor incubated for 60 mins by microbeta scintillation counting method B 7.41 pIC50 38.9 nM IC50 Medchemcomm (2019) 10: 1187-1191 [PMID:31391893]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL In vitro binding activity against opioid receptor mu using [3H]DAGO) as radioligand B 7.82 pIC50 15 nM IC50 J Med Chem (1991) 34: 827-841 [PMID:1847432]
Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492]
ChEMBL Displacement of [3H]pentazocine from LAL/HA/BR guinea pig brain sigma1 receptor incubated for 90 mins by liquid scintillation counting method B 5 pIC50 >10000 nM IC50 Medchemcomm (2019) 10: 1187-1191 [PMID:31391893]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]