ipragliflozin   Click here for help

GtoPdb Ligand ID: 9394

Synonyms: ASP-1941 | ASP1941 | Suglat®
Approved drug
ipragliflozin is an approved drug (Japan (2014))
Compound class: Synthetic organic
Comment: Ipragliflozin is a selective and orally available sodium/glucose cotransporter 2 (SGLT2; SLC5A2) inhibitor [2,4] (a 'gliflozin' family drug [1]) used to treat type 2 diabetes. In practice ipragliflozin is complexed with L-proline in a 1:1 ratio.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 118.39
Molecular weight 404.11
XLogP 2.54
No. Lipinski's rules broken 0
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Canonical SMILES OCC1OC(c2ccc(c(c2)Cc2cc3c(s2)cccc3)F)C(C(C1O)O)O
Isomeric SMILES OC[C@H]1O[C@@H](c2ccc(c(c2)Cc2cc3c(s2)cccc3)F)[C@@H]([C@H]([C@@H]1O)O)O
InChI InChI=1S/C21H21FO5S/c22-15-6-5-12(21-20(26)19(25)18(24)16(10-23)27-21)7-13(15)9-14-8-11-3-1-2-4-17(11)28-14/h1-8,16,18-21,23-26H,9-10H2/t16-,18-,19+,20-,21+/m1/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (Japan (2014))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
9258 ipragliflozin
Synonyms Click here for help
ASP-1941 | ASP1941 | Suglat®
Database Links Click here for help
BindingDB Ligand 50381554
CAS Registry No. 761423-87-4
ChEMBL Ligand CHEMBL2018096
DrugCentral Ligand 4890
GtoPdb PubChem SID 328083496
PubChem CID 10453870
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