ChEMBL ligand: CHEMBL488 (Aminoglutethimide, Cytadren, NSC-330915, Orimeten)
CYP11A1/Cytochrome P450 11A1 in Human [ChEMBL: CHEMBL2033] [GtoPdb: 1358] [UniProtKB: P05108] Cytochrome P450 11A1 in Bovine [ChEMBL: CHEMBL4813] [UniProtKB: P00189] CYP11A1 in Hamster [GtoPdb: 1358] There should be some charts here, you may need to enable JavaScript!
CYP11B2/Cytochrome P450 11B2 in Rat [ChEMBL: CHEMBL3237] [GtoPdb: 1360] [UniProtKB: P30099] There should be some charts here, you may need to enable JavaScript!
CYP17A1/Cytochrome P450 17A1 in Human [ChEMBL: CHEMBL3522] [GtoPdb: 1361] [UniProtKB: P05093] There should be some charts here, you may need to enable JavaScript!
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] CYP19A1/Cytochrome P450 19A1 in Rat [ChEMBL: CHEMBL3859] [GtoPdb: 1362] [UniProtKB: P22443] There should be some charts here, you may need to enable JavaScript!
CYP5A1/Thromboxane-A synthase in Human [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP11A1/Cytochrome P450 11A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2033] [GtoPdb: 1358] [UniProtKB: P05108]
ChEMBL	In vitro inhibition of progesterone production in hamster ovarian tissue	F	4.1	pIC50	80000	nM	IC50	J. Med. Chem. (1991) 34: 725-736 [PMID:1825337]
Cytochrome P450 11A1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4813] [UniProtKB: P00189]
ChEMBL	Inhibition of bovine desmolase, cytochrome P450 11A1	B	4.52	pIC50	30000	nM	IC50	J. Med. Chem. (1987) 30: 1550-1554 [PMID:3625703]
ChEMBL	Inhibition of bovine adrenal cholesterol side chain cleavage(CSCC) cytochrome P450 11A1	B	4.52	pIC50	30000	nM	IC50	J. Med. Chem. (1988) 31: 971-976 [PMID:3361583]
ChEMBL	Inhibition of bovine adrenal desmolase	B	4.54	pIC50	29000	nM	IC50	J. Med. Chem. (1992) 35: 2210-2214 [PMID:1613747]
CYP11A1 in Hamster [GtoPdb: 1358]
GtoPdb	Measuring inhibition of progesterone synthesis in hamster ovarian slices as an indicatior of CYP11A1 activity.	-	4.52	pIC50	30000	nM	IC50	J Med Chem (1991) 34: 725-36 [PMID:1825337]
CYP11B2/Cytochrome P450 11B2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3237] [GtoPdb: 1360] [UniProtKB: P30099]
ChEMBL	In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices	F	4.1	pIC50	80000	nM	IC50	J. Med. Chem. (1995) 38: 2103-2111 [PMID:7783141]
ChEMBL	In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices	F	4.3	pIC50	50000	nM	IC50	J. Med. Chem. (1995) 38: 2103-2111 [PMID:7783141]
CYP17A1/Cytochrome P450 17A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3522] [GtoPdb: 1361] [UniProtKB: P05093]
ChEMBL	In vitro inhibition of progesterone production in hamster ovarian tissue	F	4.22	pIC50	60000	nM	IC50	J. Med. Chem. (1991) 34: 1329-1334 [PMID:2016706]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL	Inhibition of human aromatase extracted from placental microsomes using [1,2-3H]androstenedione as substrate after 30 mins	B	5.39	pKi	4100	nM	Ki	Eur. J. Med. Chem. (2015) 105: 1-38 [PMID:26469743]
ChEMBL	Inhibition of human placental cytochrome P450 19A1 with androstenedione	B	5.74	pKi	1800	nM	Ki	J. Med. Chem. (1987) 30: 1550-1554 [PMID:3625703]
ChEMBL	Apparent inhibition constant (Ki) for cytochrome P450 19A1	B	5.74	pKi	1800	nM	Ki	J. Med. Chem. (1988) 31: 971-976 [PMID:3361583]
ChEMBL	Apparent Ki against human aromatase	B	5.85	pKi	1410	nM	Ki	J. Med. Chem. (2004) 47: 4032-4040 [PMID:15267241]
ChEMBL	Inhibitory constant against human placental atomatase at pH 7.0 and 37 degree C	B	5.85	pKi	1410	nM	Ki	Bioorg. Med. Chem. Lett. (2005) 15: 4063-4070 [PMID:15911319]
ChEMBL	Inhibition of Cytochrome P450 19A1 against testosterone at 1.5 uM (Km=0.13 uM)	B	6.17	pKi	680	nM	Ki	J. Med. Chem. (1986) 29: 520-523 [PMID:3754286]
ChEMBL	Inhibitory constant (Ki) for Cytochrome P450 19A1	B	6.22	pKi	600	nM	Ki	J. Med. Chem. (1985) 28: 200-204 [PMID:3968684]
ChEMBL	Inhibition of human placental cytochrome P450 19A1 with testosterone	B	6.22	pKi	600	nM	Ki	J. Med. Chem. (1987) 30: 1550-1554 [PMID:3625703]
ChEMBL	Binding affinity was measured on Cytochrome P450 19A1	B	6.22	pKi	600	nM	Ki	J. Med. Chem. (1990) 33: 2933-2942 [PMID:2231592]
ChEMBL	Competitive inhibition of human placental Cytochrome P450 19A1	B	6.33	pKi	470	nM	Ki	J. Med. Chem. (1991) 34: 725-736 [PMID:1825337]
ChEMBL	Inhibitory concentration against human placental aromatase as logIC50	B	3.45	pIC50	3.45	nM	Log IC50	J. Med. Chem. (2004) 47: 4032-4040 [PMID:15267241]
ChEMBL	In vitro inhibitory concentration against human placental Cytochrome P450 19A was determined using [1-beta,2beta-3H]testosterone as radioligand	B	4.43	pIC50	37000	nM	IC50	J. Med. Chem. (1991) 34: 2685-2691 [PMID:1895288]
ChEMBL	Concentration inhibiting Aromatase	B	4.43	pIC50	37000	nM	IC50	J. Med. Chem. (1992) 35: 2210-2214 [PMID:1613747]
ChEMBL	Inhibition of human placental aromatase	B	4.43	pIC50	37000	nM	IC50	J. Med. Chem. (1986) 29: 1362-1369 [PMID:3735304]
ChEMBL	In vitro inhibitory concentration against human placental Cytochrome P450 19A was determined using [1-beta,2beta-3H]testosterone as radioligand	B	4.43	pIC50	37000	nM	IC50	J. Med. Chem. (1991) 34: 2685-2691 [PMID:1895288]
ChEMBL	Inhibition of Cytochrome P450 19A1 in human placenta	B	4.52	pIC50	30000	nM	IC50	J. Med. Chem. (1990) 33: 2673-2679 [PMID:2391706]
ChEMBL	In vitro inhibition of estrogen production in hamster ovarian tissue	F	4.52	pIC50	30000	nM	IC50	J. Med. Chem. (1991) 34: 725-736 [PMID:1825337]
ChEMBL	Inhibition of CYP19	B	4.53	pIC50	29750	nM	IC50	Bioorg. Med. Chem. Lett. (2006) 16: 1134-1137 [PMID:16380254]
ChEMBL	Inhibition of aromatase in human placental microsomes	B	4.53	pIC50	29750	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 4713-4715 [PMID:18640836]
ChEMBL	Inhibition of aromatase in Homo sapiens (human) placental microsome assessed as tritiated H2O release from [1-beta-3H] androstenedione substrate preincubated with substrate for 5 min prior to enzyme addition measured after 20 min by beta-scintillation counting analysis	B	4.55	pIC50	28500	nM	IC50	Med Chem Res (2013) 22: 692-698
ChEMBL	Inhibition of Homo sapiens (human) aromatase assessed as 3H2O formation using [1beta,2beta-3H]testosterone as substrate by liquid scintillation counting analysis	B	4.55	pIC50	28500	nM	IC50	Med Chem Res (2011) 20: 661-669
ChEMBL	Inhibition of human placental microsome cytochrome P450 19A1 aromatase	B	4.73	pIC50	18500	nM	IC50	J. Med. Chem. (2001) 44: 672-680 [PMID:11262078]
ChEMBL	Inhibition of Human placental Cytochrome P450 19A1	B	4.73	pIC50	18500	nM	IC50	J. Med. Chem. (1995) 38: 2103-2111 [PMID:7783141]
ChEMBL	Inhibition of human placental aromatase, cytochrome P450 19A1	B	4.73	pIC50	18500	nM	IC50	Bioorg. Med. Chem. Lett. (1999) 9: 2105-2108 [PMID:10450990]
ChEMBL	Inhibition of cytochrome P450 19A1 of human placental microsomes with [1-beta,2beta-3H]testosterone	B	4.73	pIC50	18500	nM	IC50	Bioorg. Med. Chem. Lett. (2003) 13: 1553-1555 [PMID:12699753]
ChEMBL	Inhibition of human placental cytochrome P450 19A1 with androstenedione	B	4.85	pIC50	14000	nM	IC50	J. Med. Chem. (1988) 31: 971-976 [PMID:3361583]
ChEMBL	Inhibition of human placental cytochrome P450 19A1 with androstenedione	B	4.85	pIC50	14000	nM	IC50	J. Med. Chem. (1987) 30: 1550-1554 [PMID:3625703]
ChEMBL	In vitro inhibition of estrogen production in hamster ovarian tissue	F	4.89	pIC50	13000	nM	IC50	J. Med. Chem. (1991) 34: 1329-1334 [PMID:2016706]
ChEMBL	Inhibition of human aromatase transfected in human MCF7 cells	B	5	pIC50	10000	nM	IC50	J. Med. Chem. (2016) 59: 5131-5148 [PMID:26689671]
ChEMBL	Inhibition of human placental aromatase assessed as conversion of [1-beta-3H]androstenedione to [1beta-3H]estrone after 20 mins by liquid scintillation counting	B	5	pIC50	10000	nM	IC50	Eur. J. Med. Chem. (2009) 44: 4121-4127 [PMID:19500885]
ChEMBL	Inhibition of CYP19 in human placental microsome using [1beta-3H]-androstenedione as substrate after 15 mins in presence of NADPH by liquid scintillation counter method	B	5.05	pIC50	9000	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2645-2649 [PMID:28512028]
ChEMBL	Inhibition of Cytochrome P450 19A1 against Androstenedione at 0.25 uM (Km=55 nM)	B	5.08	pIC50	8300	nM	IC50	J. Med. Chem. (1986) 29: 520-523 [PMID:3754286]
ChEMBL	Inhibitory activity against human placental cytochrome P450 19A1	B	5.1	pIC50	8000	nM	IC50	J. Med. Chem. (1987) 30: 1550-1554 [PMID:3625703]
ChEMBL	Inhibition of human placental cytochrome P450 19A1 with testosterone	B	5.1	pIC50	8000	nM	IC50	J. Med. Chem. (1988) 31: 971-976 [PMID:3361583]
ChEMBL	Inhibition of human CYP19 using [1beta-3H]-androstenedione as substrate after 15 mins in presence of NADPH by liquid scintillation counter method	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2645-2649 [PMID:28512028]
ChEMBL	Inhibition of aromatase from human placental microsomes	B	5.19	pIC50	6400	nM	IC50	J. Nat. Prod. (2001) 64: 1286-1293 [PMID:11678652]
ChEMBL	Inhibition of human aromatase in term placenta microsome assessed as radioactivity	B	5.19	pIC50	6400	nM	IC50	Eur. J. Med. Chem. (2015) 90: 379-393 [PMID:25461329]
ChEMBL	Inhibition of Cytochrome P450 19A1 against testosterone at 1.5 uM (Km=0.13 uM)	B	5.21	pIC50	6130	nM	IC50	J. Med. Chem. (1986) 29: 520-523 [PMID:3754286]
ChEMBL	Inhibition of aromatase in human placental microsomes assessed as inhibition of aromatization of [1,2,6,7-3H] androstenedione by flow scintillation analysis	B	5.24	pIC50	5800	nM	IC50	Eur. J. Med. Chem. (2011) 46: 2541-2545 [PMID:21497425]
ChEMBL	In vitro inhibition of [1,2,6,7-3H]-androstenedione binding to human placental microsome cytochrome P450 19A1	B	5.28	pIC50	5200	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 1059-1061 [PMID:11909717]
ChEMBL	Inhibition of aromatase activity in human placental microsomes	B	5.28	pIC50	5200	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 2859-2861 [PMID:12270163]
ChEMBL	Inhibitory concentration against human placental aromatase by deutirium oxide release	B	5.55	pIC50	2800	nM	IC50	Bioorg. Med. Chem. Lett. (2005) 15: 4063-4070 [PMID:15911319]
ChEMBL	Inhibitory concentration against human placental aromatase	B	5.55	pIC50	2800	nM	IC50	J. Med. Chem. (2004) 47: 4032-4040 [PMID:15267241]
ChEMBL	In vitro inhibition of human placental Cytochrome P450 19A1	B	5.72	pIC50	1900	nM	IC50	J. Med. Chem. (1993) 36: 1393-1400 [PMID:8496907]
ChEMBL	In vitro inhibition of cytochrome P450 19A1 Aromatase	B	5.72	pIC50	1900	nM	IC50	J. Med. Chem. (1991) 34: 1329-1334 [PMID:2016706]
ChEMBL	Inhibition of human placental microsome cytochrome P450 19A1	B	5.77	pIC50	1700	nM	IC50	J. Med. Chem. (1991) 34: 725-736 [PMID:1825337]
ChEMBL	Inhibition of aromatase after 30 mins by fluorescence assay	B	6.57	pIC50	270	nM	IC50	J. Med. Chem. (2009) 52: 1873-1884 [PMID:19265439]
ChEMBL	Inhibition of human aromatase	B	6.57	pIC50	270	nM	IC50	J. Med. Chem. (2007) 50: 2799-2806 [PMID:17511439]
ChEMBL	Inhibition of human placental microsome CYP19	B	8.28	pIC50	5.2	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 3050-3064 [PMID:20413308]
CYP19A1/Cytochrome P450 19A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3859] [GtoPdb: 1362] [UniProtKB: P22443]
ChEMBL	Inhibition of rat ovarian Cytochrome P450 19A	B	4.47	pIC50	34000	nM	IC50	J. Med. Chem. (1991) 34: 2685-2691 [PMID:1895288]
ChEMBL	In vitro inhibition of rat ovarian microsomal Cytochrome P450 19A1	B	5.21	pIC50	6200	nM	IC50	J. Med. Chem. (1995) 38: 2103-2111 [PMID:7783141]
ChEMBL	In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.	B	6.59	pEC50	260	nM	EC50	J. Med. Chem. (1987) 30: 1359-1365 [PMID:3612685]
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
ChEMBL	Inhibition of Thromboxane-A synthase	B	4.73	pIC50	18500	nM	IC50	J. Med. Chem. (2000) 43: 1841-1851 [PMID:10794700]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]