ChEMBL ligand: CHEMBL488 (Aminoglutethimide, Cytadren, NSC-330915, Orimeten)
CYP11A1/Cytochrome P450 11A1 in Human [ChEMBL: CHEMBL2033] [GtoPdb: 1358] [UniProtKB: P05108] Cytochrome P450 11A1 in Bovine [ChEMBL: CHEMBL4813] [UniProtKB: P00189] CYP11A1 in Hamster [GtoPdb: 1358] There should be some charts here, you may need to enable JavaScript!
CYP11B2/Cytochrome P450 11B2 in Rat [ChEMBL: CHEMBL3237] [GtoPdb: 1360] [UniProtKB: P30099] There should be some charts here, you may need to enable JavaScript!
CYP17A1/Cytochrome P450 17A1 in Human [ChEMBL: CHEMBL3522] [GtoPdb: 1361] [UniProtKB: P05093] There should be some charts here, you may need to enable JavaScript!
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] CYP19A1/Cytochrome P450 19A1 in Rat [ChEMBL: CHEMBL3859] [GtoPdb: 1362] [UniProtKB: P22443] There should be some charts here, you may need to enable JavaScript!
CYP5A1/Thromboxane-A synthase in Human [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP11A1/Cytochrome P450 11A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2033] [GtoPdb: 1358] [UniProtKB: P05108]
ChEMBL	In vitro inhibition of progesterone production in hamster ovarian tissue	F	4.1	pIC50	80000	nM	IC50	J Med Chem (1991) 34: 725-736 [PMID:1825337]
Cytochrome P450 11A1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4813] [UniProtKB: P00189]
ChEMBL	Inhibition of bovine desmolase, cytochrome P450 11A1	B	4.52	pIC50	30000	nM	IC50	J Med Chem (1987) 30: 1550-1554 [PMID:3625703]
ChEMBL	Inhibition of bovine adrenal cholesterol side chain cleavage(CSCC) cytochrome P450 11A1	B	4.52	pIC50	30000	nM	IC50	J Med Chem (1988) 31: 971-976 [PMID:3361583]
ChEMBL	Inhibition of bovine adrenal desmolase	B	4.54	pIC50	29000	nM	IC50	J Med Chem (1992) 35: 2210-2214 [PMID:1613747]
CYP11A1 in Hamster [GtoPdb: 1358]
GtoPdb	Measuring inhibition of progesterone synthesis in hamster ovarian slices as an indicatior of CYP11A1 activity.	-	4.52	pIC50	30000	nM	IC50	J Med Chem (1991) 34: 725-36 [PMID:1825337]
CYP11B2/Cytochrome P450 11B2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3237] [GtoPdb: 1360] [UniProtKB: P30099]
ChEMBL	In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices	F	4.1	pIC50	80000	nM	IC50	J Med Chem (1995) 38: 2103-2111 [PMID:7783141]
ChEMBL	In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices	F	4.3	pIC50	50000	nM	IC50	J Med Chem (1995) 38: 2103-2111 [PMID:7783141]
CYP17A1/Cytochrome P450 17A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3522] [GtoPdb: 1361] [UniProtKB: P05093]
ChEMBL	In vitro inhibition of progesterone production in hamster ovarian tissue	F	4.22	pIC50	60000	nM	IC50	J Med Chem (1991) 34: 1329-1334 [PMID:2016706]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL	Inhibition of human aromatase extracted from placental microsomes using [1,2-3H]androstenedione as substrate after 30 mins	B	5.39	pKi	4100	nM	Ki	Eur J Med Chem (2015) 105: 1-38 [PMID:26469743]
ChEMBL	Inhibition of human placental cytochrome P450 19A1 with androstenedione	B	5.74	pKi	1800	nM	Ki	J Med Chem (1987) 30: 1550-1554 [PMID:3625703]
ChEMBL	Apparent inhibition constant (Ki) for cytochrome P450 19A1	B	5.74	pKi	1800	nM	Ki	J Med Chem (1988) 31: 971-976 [PMID:3361583]
ChEMBL	Apparent Ki against human aromatase	B	5.85	pKi	1410	nM	Ki	J Med Chem (2004) 47: 4032-4040 [PMID:15267241]
ChEMBL	Inhibitory constant against human placental atomatase at pH 7.0 and 37 degree C	B	5.85	pKi	1410	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4063-4070 [PMID:15911319]
ChEMBL	Inhibition of Cytochrome P450 19A1 against testosterone at 1.5 uM (Km=0.13 uM)	B	6.17	pKi	680	nM	Ki	J Med Chem (1986) 29: 520-523 [PMID:3754286]
ChEMBL	Inhibitory constant (Ki) for Cytochrome P450 19A1	B	6.22	pKi	600	nM	Ki	J Med Chem (1985) 28: 200-204 [PMID:3968684]
ChEMBL	Inhibition of human placental cytochrome P450 19A1 with testosterone	B	6.22	pKi	600	nM	Ki	J Med Chem (1987) 30: 1550-1554 [PMID:3625703]
ChEMBL	Binding affinity was measured on Cytochrome P450 19A1	B	6.22	pKi	600	nM	Ki	J Med Chem (1990) 33: 2933-2942 [PMID:2231592]
ChEMBL	Competitive inhibition of human placental Cytochrome P450 19A1	B	6.33	pKi	470	nM	Ki	J Med Chem (1991) 34: 725-736 [PMID:1825337]
ChEMBL	Inhibitory concentration against human placental aromatase as logIC50	B	3.45	pIC50	3.45	nM	Log IC50	J Med Chem (2004) 47: 4032-4040 [PMID:15267241]
ChEMBL	In vitro inhibitory concentration against human placental Cytochrome P450 19A was determined using [1-beta,2beta-3H]testosterone as radioligand	B	4.43	pIC50	37000	nM	IC50	J Med Chem (1991) 34: 2685-2691 [PMID:1895288]
ChEMBL	Concentration inhibiting Aromatase	B	4.43	pIC50	37000	nM	IC50	J Med Chem (1992) 35: 2210-2214 [PMID:1613747]
ChEMBL	Inhibition of human placental aromatase	B	4.43	pIC50	37000	nM	IC50	J Med Chem (1986) 29: 1362-1369 [PMID:3735304]
ChEMBL	In vitro inhibitory concentration against human placental Cytochrome P450 19A was determined using [1-beta,2beta-3H]testosterone as radioligand	B	4.43	pIC50	37000	nM	IC50	J Med Chem (1991) 34: 2685-2691 [PMID:1895288]
ChEMBL	Inhibition of Cytochrome P450 19A1 in human placenta	B	4.52	pIC50	30000	nM	IC50	J Med Chem (1990) 33: 2673-2679 [PMID:2391706]
ChEMBL	In vitro inhibition of estrogen production in hamster ovarian tissue	F	4.52	pIC50	30000	nM	IC50	J Med Chem (1991) 34: 725-736 [PMID:1825337]
ChEMBL	Inhibition of aromatase in human placental microsomes	B	4.53	pIC50	29750	nM	IC50	Bioorg Med Chem Lett (2008) 18: 4713-4715 [PMID:18640836]
ChEMBL	Inhibition of CYP19	B	4.53	pIC50	29750	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1134-1137 [PMID:16380254]
ChEMBL	Inhibition of aromatase in Homo sapiens (human) placental microsome assessed as tritiated H2O release from [1-beta-3H] androstenedione substrate preincubated with substrate for 5 min prior to enzyme addition measured after 20 min by beta-scintillation counting analysis	B	4.55	pIC50	28500	nM	IC50	Med Chem Res (2013) 22: 692-698
ChEMBL	Inhibition of Homo sapiens (human) aromatase assessed as 3H2O formation using [1beta,2beta-3H]testosterone as substrate by liquid scintillation counting analysis	B	4.55	pIC50	28500	nM	IC50	Med Chem Res (2011) 20: 661-669
ChEMBL	Inhibition of cytochrome P450 19A1 of human placental microsomes with [1-beta,2beta-3H]testosterone	B	4.73	pIC50	18500	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1553-1555 [PMID:12699753]
ChEMBL	Inhibition of human placental microsome cytochrome P450 19A1 aromatase	B	4.73	pIC50	18500	nM	IC50	J Med Chem (2001) 44: 672-680 [PMID:11262078]
ChEMBL	Inhibition of Human placental Cytochrome P450 19A1	B	4.73	pIC50	18500	nM	IC50	J Med Chem (1995) 38: 2103-2111 [PMID:7783141]
ChEMBL	Inhibition of human placental aromatase, cytochrome P450 19A1	B	4.73	pIC50	18500	nM	IC50	Bioorg Med Chem Lett (1999) 9: 2105-2108 [PMID:10450990]
ChEMBL	Inhibition of human placental cytochrome P450 19A1 with androstenedione	B	4.85	pIC50	14000	nM	IC50	J Med Chem (1988) 31: 971-976 [PMID:3361583]
ChEMBL	Inhibition of human placental cytochrome P450 19A1 with androstenedione	B	4.85	pIC50	14000	nM	IC50	J Med Chem (1987) 30: 1550-1554 [PMID:3625703]
ChEMBL	In vitro inhibition of estrogen production in hamster ovarian tissue	F	4.89	pIC50	13000	nM	IC50	J Med Chem (1991) 34: 1329-1334 [PMID:2016706]
ChEMBL	Inhibition of aromatase in human breast tumor	B	5	pIC50	10000	nM	IC50	Eur J Med Chem (2022) 241: 114658-114658 [PMID:35964426]
ChEMBL	Inhibition of human placental aromatase assessed as conversion of [1-beta-3H]androstenedione to [1beta-3H]estrone after 20 mins by liquid scintillation counting	B	5	pIC50	10000	nM	IC50	Eur J Med Chem (2009) 44: 4121-4127 [PMID:19500885]
ChEMBL	Inhibition of human aromatase transfected in human MCF7 cells	B	5	pIC50	10000	nM	IC50	J Med Chem (2016) 59: 5131-5148 [PMID:26689671]
ChEMBL	Inhibition of CYP19 in human placental microsome using [1beta-3H]-androstenedione as substrate after 15 mins in presence of NADPH by liquid scintillation counter method	B	5.05	pIC50	9000	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2645-2649 [PMID:28512028]
ChEMBL	Inhibition of Cytochrome P450 19A1 against Androstenedione at 0.25 uM (Km=55 nM)	B	5.08	pIC50	8300	nM	IC50	J Med Chem (1986) 29: 520-523 [PMID:3754286]
ChEMBL	Inhibitory activity against human placental cytochrome P450 19A1	B	5.1	pIC50	8000	nM	IC50	J Med Chem (1987) 30: 1550-1554 [PMID:3625703]
ChEMBL	Inhibition of human placental cytochrome P450 19A1 with testosterone	B	5.1	pIC50	8000	nM	IC50	J Med Chem (1988) 31: 971-976 [PMID:3361583]
ChEMBL	Inhibition of human CYP19 using [1beta-3H]-androstenedione as substrate after 15 mins in presence of NADPH by liquid scintillation counter method	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2645-2649 [PMID:28512028]
ChEMBL	Inhibition of human aromatase in term placenta microsome assessed as radioactivity	B	5.19	pIC50	6400	nM	IC50	Eur J Med Chem (2015) 90: 379-393 [PMID:25461329]
ChEMBL	Inhibition of aromatase from human placental microsomes	B	5.19	pIC50	6400	nM	IC50	J Nat Prod (2001) 64: 1286-1293 [PMID:11678652]
ChEMBL	Inhibition of Cytochrome P450 19A1 against testosterone at 1.5 uM (Km=0.13 uM)	B	5.21	pIC50	6130	nM	IC50	J Med Chem (1986) 29: 520-523 [PMID:3754286]
ChEMBL	Inhibition of aromatase in human placental microsomes assessed as inhibition of aromatization of [1,2,6,7-3H] androstenedione by flow scintillation analysis	B	5.24	pIC50	5800	nM	IC50	Eur J Med Chem (2011) 46: 2541-2545 [PMID:21497425]
ChEMBL	Inhibition of aromatase activity in human placental microsomes	B	5.28	pIC50	5200	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2859-2861 [PMID:12270163]
ChEMBL	In vitro inhibition of [1,2,6,7-3H]-androstenedione binding to human placental microsome cytochrome P450 19A1	B	5.28	pIC50	5200	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1059-1061 [PMID:11909717]
ChEMBL	Inhibitory concentration against human placental aromatase	B	5.55	pIC50	2800	nM	IC50	J Med Chem (2004) 47: 4032-4040 [PMID:15267241]
ChEMBL	Inhibitory concentration against human placental aromatase by deutirium oxide release	B	5.55	pIC50	2800	nM	IC50	Bioorg Med Chem Lett (2005) 15: 4063-4070 [PMID:15911319]
ChEMBL	In vitro inhibition of cytochrome P450 19A1 Aromatase	B	5.72	pIC50	1900	nM	IC50	J Med Chem (1991) 34: 1329-1334 [PMID:2016706]
ChEMBL	In vitro inhibition of human placental Cytochrome P450 19A1	B	5.72	pIC50	1900	nM	IC50	J Med Chem (1993) 36: 1393-1400 [PMID:8496907]
ChEMBL	Inhibition of human placental microsome cytochrome P450 19A1	B	5.77	pIC50	1700	nM	IC50	J Med Chem (1991) 34: 725-736 [PMID:1825337]
ChEMBL	Inhibition of aromatase after 30 mins by fluorescence assay	B	6.57	pIC50	270	nM	IC50	J Med Chem (2009) 52: 1873-1884 [PMID:19265439]
ChEMBL	Inhibition of human aromatase	B	6.57	pIC50	270	nM	IC50	J Med Chem (2007) 50: 2799-2806 [PMID:17511439]
ChEMBL	Inhibition of human placental microsome CYP19	B	8.28	pIC50	5.2	nM	IC50	Bioorg Med Chem Lett (2010) 20: 3050-3064 [PMID:20413308]
CYP19A1/Cytochrome P450 19A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3859] [GtoPdb: 1362] [UniProtKB: P22443]
ChEMBL	Inhibition of rat ovarian Cytochrome P450 19A	B	4.47	pIC50	34000	nM	IC50	J Med Chem (1991) 34: 2685-2691 [PMID:1895288]
ChEMBL	In vitro inhibition of rat ovarian microsomal Cytochrome P450 19A1	B	5.21	pIC50	6200	nM	IC50	J Med Chem (1995) 38: 2103-2111 [PMID:7783141]
ChEMBL	In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.	B	6.59	pEC50	260	nM	EC50	J Med Chem (1987) 30: 1359-1365 [PMID:3612685]
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
ChEMBL	Inhibition of Thromboxane-A synthase	B	4.73	pIC50	18500	nM	IC50	J Med Chem (2000) 43: 1841-1851 [PMID:10794700]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]