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CYP11B2

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Target not currently curated in GtoImmuPdb

Target id: 1360

Nomenclature: CYP11B2

Abbreviated Name: Aldosterone synthase

Family: CYP11, CYP17, CYP19, CYP20 and CYP21 families

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 503 8q24.3 CYP11B2 cytochrome P450 family 11 subfamily B member 2
Mouse - 500 15 34.29 cM Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2
Rat - - Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2
Previous and Unofficial Names Click here for help
ALDOS | aldosterone-synthesizing enzyme | cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2 | cytochrome P450 11B2, mitochondrial | Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase) | cytochrome P450, family 11, subfamily b, polypeptide 2 | cytochrome P450
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.14.15.4
EC Number: 1.14.15.5

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
fadrozole Small molecule or natural product Approved drug Click here for species-specific activity table Hs Inhibition 9.1 pKi 1
pKi 9.1 (Ki 8x10-10 M) [1]
osilodrostat Small molecule or natural product Approved drug Click here for species-specific activity table Hs Inhibition 9.7 pIC50 2
pIC50 9.7 (IC50 2x10-10 M) [2]

References

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1. LaSala D, Shibanaka Y, Jeng AY. (2009) Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors. Anal. Biochem., 394 (1): 56-61. [PMID:19622340]

2. Yin L, Hu Q, Emmerich J, Lo MM, Metzger E, Ali A, Hartmann RW. (2014) Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J. Med. Chem., 57 (12): 5179-89. [PMID:24899257]

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