ChEMBL ligand: CHEMBL1615434
lysine demethylase 1A/Lysine-specific histone demethylase 1A in Human [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341] There should be some charts here, you may need to enable JavaScript!
P2Y12 receptor/P2Y purinoceptor 12 in Human [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] There should be some charts here, you may need to enable JavaScript!
TRPC5/Short transient receptor potential channel 5 in Human [ChEMBL: CHEMBL1250411] [GtoPdb: 490] [UniProtKB: Q9UL62] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor beta in Human [GtoPdb: 1804] [UniProtKB: P09619] There should be some charts here, you may need to enable JavaScript!
Piezo1 in Human [GtoPdb: 2945] [UniProtKB: Q92508] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
lysine demethylase 1A/Lysine-specific histone demethylase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341]
ChEMBL	Inhibition of LSD1 (unknown origin) by Spectra Max Paradigm Microplate Reader analysis	B	6.96	pIC50	110	nM	IC50	Eur J Med Chem (2021) 214: 113254-113254 [PMID:33581557]
ChEMBL	Inhibition of LSD1 (unknown origin) by microplate reader method	B	6.96	pIC50	110	nM	IC50	Eur J Med Chem (2022) 240: 114564-114564 [PMID:35820351]
GtoPdb	-	-	6.96	pIC50	110	nM	IC50	Talanta (2020) 206: 120195 [PMID:31514831]
P2Y12 receptor/P2Y purinoceptor 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
ChEMBL	Displacement of [3H]2MeSADP from human P2Y12 expressed in U2OS cell membranes incubated for 60 mins by scintillation counting method	B	4.44	pKi	36400	nM	Ki	Eur J Med Chem (2022) 227: 113924-113924 [PMID:34731765]
TRPC5/Short transient receptor potential channel 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250411] [GtoPdb: 490] [UniProtKB: Q9UL62]
ChEMBL	Antagonist activity at human TRPC5 expressed in HEK293 cells assessed as inhibition of calcium influx by calcium fluorescence assay	B	5.86	pIC50	1370	nM	IC50	Eur J Med Chem (2024) 273: 116502-116502 [PMID:38761789]
platelet derived growth factor receptor beta in Human [GtoPdb: 1804] [UniProtKB: P09619]
GtoPdb	Binding affinity determined by surface plasmon resonance analysis	-	5.21	pKd	6150	nM	Kd	Int Immunopharmacol (2023) 122: 110550 [PMID:37451016]
Piezo1 in Human [GtoPdb: 2945] [UniProtKB: Q92508]
GtoPdb	-	-	5.9	pIC50	-	-	-	Br J Pharmacol (2022) 179: 3778-3814 [PMID:35194776]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]