nilutamide [Ligand Id: 2864] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1274 (Anadron, Nilandron, Nilutamide, NSC-758683, RU 23908, RU-23908) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| ChEMBL | Inhibition of wild-type androgen receptor in human LAPC4 cells assessed as inhibition of DHT-induced luciferase activity measured after 24 hrs by luciferase reporter assay | B | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (2016) 59: 10705-10718 [PMID:27933964] |
| GtoPdb | - | - | 7.12 | pIC50 | 75 | nM | IC50 | Urology (1997) 49: 580-6; discussion 586-9 [PMID:9111629] |
| ChEMBL | Inhibition of 1.0 nM [3H]mibolerone binding to human androgen receptor of PC3/AR cell lysate | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2003) 46: 5258-5270 [PMID:14613328] |
| ChEMBL | Inhibition of [3H]mibolerone binding to human Androgen receptor of PC3/AR Cell Lysate | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2004) 47: 5690-5699 [PMID:15509168] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
