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ChEMBL ligand: CHEMBL515288 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CCK1 receptor/Cholecystokinin A receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238] | ||||||||
ChEMBL | Displacement of [125I](S)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea from human CCK1 receptor expressed in CHO cells by gamma spectrometry | B | 8.43 | pKi | 3.71 | nM | Ki | J. Med. Chem. (2009) 52: 2138-2147 [PMID:19271701] |
CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
ChEMBL | Binding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assay | B | 8.53 | pKd | 2.95 | nM | Kd | J. Med. Chem. (2009) 52: 2138-2147 [PMID:19271701] |
ChEMBL | Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry | B | 6.27 | pKi | 537.03 | nM | Ki | J. Med. Chem. (2009) 52: 2138-2147 [PMID:19271701] |
GtoPdb | - | - | 8.4 | pKi | 3.98 | nM | Ki | J Med Chem (2009) 52: 2138-47 [PMID:19271701] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]