piritrexim [Ligand Id: 7414] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL7492 (Bw 301u, Bw-301u, BW-301U, Piritrexim, TCMDC-137235)
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  • Dihydrofolate reductase in Escherichia coli [ChEMBL: CHEMBL1809] [UniProtKB: P0ABQ4]
  • Dihydrofolate reductase in Lactobacillus casei [ChEMBL: CHEMBL2902] [UniProtKB: P00381]
  • Dihydrofolate reductase in Mycobacterium avium [ChEMBL: CHEMBL5457] [UniProtKB: O30463]
  • Dihydrofolate reductase in Pneumocystis carinii [ChEMBL: CHEMBL1926] [UniProtKB: P16184]
  • Dihydrofolate reductase in Candida albicans [ChEMBL: CHEMBL2329] [UniProtKB: P22906]
  • Dihydrofolate reductase in Toxoplasma gondii [ChEMBL: CHEMBL2425] [UniProtKB: Q07422]
  • dihydrofolate reductase/Dihydrofolate reductase in Human [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
  • dihydrofolate reductase/Dihydrofolate reductase in Rat [ChEMBL: CHEMBL2363] [GtoPdb: 2603] [UniProtKB: Q920D2]
  • Dihydrofolate reductase in Pneumocystis jirovecii [ChEMBL: CHEMBL2057] [UniProtKB: Q9UUP5]
  • Dihydrofolate reductase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL2576] [UniProtKB: P07807]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Bacterial dihydrofolate reductase in Bacteria (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2364669] [UniProtKB: P0ABQ4]
ChEMBL In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase. B 7.51 pIC50 31 nM IC50 J Med Chem (2002) 45: 233-241 [PMID:11754594]
Dihydrofolate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1809] [UniProtKB: P0ABQ4]
ChEMBL Inhibition of dihydrofolate reductase in pneumocystis carinii. B 7.42 pIC50 38 nM IC50 J Med Chem (1993) 36: 3103-3112 [PMID:8230096]
ChEMBL Inhibition of dihydrofolate reductase from pneumocystis carinii. B 7.51 pIC50 31 nM IC50 J Med Chem (2003) 46: 5074-5082 [PMID:14584957]
ChEMBL Inhibition of dihydrofolate reductase in Toxoplasma gondii. B 7.96 pIC50 11 nM IC50 J Med Chem (1993) 36: 3103-3112 [PMID:8230096]
ChEMBL Inhibition of dihydrofolate reductase from Toxoplasma gondii. B 7.96 pIC50 11 nM IC50 J Med Chem (2003) 46: 5074-5082 [PMID:14584957]
Dihydrofolate reductase in Lactobacillus casei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2902] [UniProtKB: P00381]
ChEMBL Inhibitory activity against dihydrofolate reductase in mammalians. (high potency) B 8.82 pIC50 1.5 nM IC50 J Med Chem (1995) 38: 4739-4759 [PMID:7490723]
Dihydrofolate reductase in Mycobacterium avium (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5457] [UniProtKB: O30463]
ChEMBL Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium B 9.21 pIC50 0.61 nM IC50 J Med Chem (2004) 47: 1475-1486 [PMID:14998335]
ChEMBL Inhibitory concentration against Mycobacterium avium dihydrofolate reductase B 9.21 pIC50 0.61 nM IC50 Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078]
ChEMBL Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range: 0.53-0.70 B 9.21 pIC50 0.61 nM IC50 J Med Chem (2004) 47: 2475-2485 [PMID:15115391]
ChEMBL Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium avium B 9.21 pIC50 0.61 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibitory concentration against Mycobacterium avium DHFR B 9.21 pIC50 0.61 nM IC50 J Med Chem (2005) 48: 4420-4431 [PMID:15974594]
Dihydrofolate reductase in Pneumocystis carinii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926] [UniProtKB: P16184]
ChEMBL Binding affinity was reported with purified recombinant Pneumocystis carinii Dihydrofolate reductase B 9.84 pKi 0.14 nM Ki J Med Chem (1995) 38: 4739-4759 [PMID:7490723]
ChEMBL Inhibitory concentration against Dihydrofolate reductase from Pneumocystis carinii (pc) B 7.42 pIC50 38 nM IC50 J Med Chem (1997) 40: 470-478 [PMID:9046337]
ChEMBL Inhibition of Pneumocystis carinii (pc) Dihydrofolate reductase B 7.42 pIC50 38 nM IC50 J Med Chem (1995) 38: 2158-2165 [PMID:7783147]
ChEMBL Inhibition of dihydrofolate reductase (DHFR) from Pneumocystis carinii(pc) B 7.42 pIC50 38 nM IC50 J Med Chem (1999) 42: 2447-2455 [PMID:10395486]
ChEMBL Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii B 7.42 pIC50 38 nM IC50 J Med Chem (1995) 38: 1778-1785 [PMID:7752201]
ChEMBL Inhibition against Dihydrofolate reductase in Pneumocystis carinii B 7.42 pIC50 38 nM IC50 J Med Chem (1997) 40: 1173-1177 [PMID:9089339]
ChEMBL Inhibition of Pneumocystis carinii dihydrofolate reductase B 7.42 pIC50 38 nM IC50 J Med Chem (1993) 36: 3437-3443 [PMID:8230134]
ChEMBL Inhibition of Dihydrofolate Reductase of Pneumocystis carinii. B 7.42 pIC50 38 nM IC50 J Med Chem (1997) 40: 479-485 [PMID:9046338]
ChEMBL Inhibition of Pneumocystis carinii dihydrofolate reductase B 7.46 pIC50 34.3 nM IC50 J Med Chem (2008) 51: 6195-6200 [PMID:18771252]
ChEMBL Inhibitory concentration against dihydrofolate reductase dihydrofolate reductase from Pneumocystis carinii. B 7.47 pIC50 34 nM IC50 J Med Chem (2001) 44: 2391-2402 [PMID:11448221]
ChEMBL Inhibition of Pneumocystis carinii dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Inhibition of Pneumocystis carinii dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii. (high potency) B 7.51 pIC50 31 nM IC50 J Med Chem (1995) 38: 4739-4759 [PMID:7490723]
ChEMBL Compound was tested for inhibition activity against pneumocystis carinii (Pneumocystis carinii) Dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1998) 41: 913-918 [PMID:9526565]
ChEMBL Inhibitory activity against Pneumocystis carinii dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1996) 39: 1271-1280 [PMID:8632434]
ChEMBL Inhibitory activity against Pneumocystis carinii Dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibitory concentration against Pneumocystis carinii Dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1997) 40: 1930-1936 [PMID:9191971]
ChEMBL The ability to inhibit Pneumocystis carinii Dihydrofolate reductase was tested B 7.51 pIC50 31 nM IC50 J Med Chem (1999) 42: 1007-1017 [PMID:10090784]
ChEMBL Concentration inhibiting Pneumocystis carinii dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1995) 38: 2615-2620 [PMID:7629801]
ChEMBL Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii was evaluated using 90 uM dihydrofolic acid as substrate B 7.51 pIC50 31 nM IC50 J Med Chem (1997) 40: 3040-3048 [PMID:9301666]
ChEMBL Inhibitory activity against dihydrofolate reductase (DHFR) from Pneumocystis carinii B 7.51 pIC50 31 nM IC50 J Med Chem (1998) 41: 4533-4541 [PMID:9804692]
ChEMBL Inhibition of Dihydrofolate reductase of Pneumocystis carinii B 7.51 pIC50 31 nM IC50 J Med Chem (1994) 37: 4522-4528 [PMID:7799402]
ChEMBL Inhibitory activity against Pneumocystis. carinii DHFR* B 7.51 pIC50 31 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii at 37 centigrade. B 7.72 pIC50 19 nM IC50 J Med Chem (1995) 38: 4739-4759 [PMID:7490723]
ChEMBL Inhibition of Pneumocystis carinii DHFR by spectrophotometric assay B 7.72 pIC50 19 nM IC50 Eur J Med Chem (2015) 95: 76-95 [PMID:25794791]
ChEMBL Inhibition of Dihydrohydrofolate reductase(DHFR) of Pneumocystis carinii B 7.89 pIC50 13 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibitory concentration against Pneumocystis carinii dihydrofolate reductase B 7.89 pIC50 13 nM IC50 Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078]
ChEMBL Inhibitory concentration against Pneumocystis carinii DHFR B 7.89 pIC50 13 nM IC50 J Med Chem (2005) 48: 4420-4431 [PMID:15974594]
ChEMBL Inhibitory concentration against dihydrofolate reductace enzyme of Pneumocystis carinii B 7.89 pIC50 13 nM IC50 J Med Chem (2004) 47: 1475-1486 [PMID:14998335]
ChEMBL Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range: 9.0-17 B 7.89 pIC50 13 nM IC50 J Med Chem (2004) 47: 2475-2485 [PMID:15115391]
ChEMBL Inhibition of Pneumocystis carinii DHFR B 7.89 pIC50 13 nM IC50 J Med Chem (2013) 56: 4422-4441 [PMID:23627352]
Dihydrofolate reductase in Candida albicans (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2329] [UniProtKB: P22906]
ChEMBL Inhibition of Dihydrofolate reductase enzyme from Candida albicans B 8.72 pKi 1.9 nM Ki J Med Chem (1996) 39: 892-903 [PMID:8632413]
ChEMBL Inhibition of dihydrofolate reductase in Candida albicans (in vitro). B 7.4 pIC50 40 nM IC50 J Med Chem (1995) 38: 3608-3616 [PMID:7658448]
Dihydrofolate reductase in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2425] [UniProtKB: Q07422]
ChEMBL Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondii B 7.37 pIC50 43 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibition of Toxoplasma gondii dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay B 7.77 pIC50 17 nM IC50 Eur J Med Chem (2015) 95: 76-95 [PMID:25794791]
ChEMBL Inhibitory activity against Toxoplasma gondii dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1996) 39: 1271-1280 [PMID:8632434]
ChEMBL Inhibitory activity against Toxoplasma gondii Dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibitory concentration against Toxoplasma gondii Dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1997) 40: 1930-1936 [PMID:9191971]
ChEMBL The ability to inhibit Toxoplasma gondii Dihydrofolate reductase was tested B 7.77 pIC50 17 nM IC50 J Med Chem (1999) 42: 1007-1017 [PMID:10090784]
ChEMBL Concentration inhibiting Toxoplasma gondii dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1995) 38: 2615-2620 [PMID:7629801]
ChEMBL Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii was evaluated using 90 uM dihydrofolic acid as substrate B 7.77 pIC50 17 nM IC50 J Med Chem (1997) 40: 3040-3048 [PMID:9301666]
ChEMBL Inhibitory activity against dihydrofolate reductase (DHFR) from Toxoplasma gondii B 7.77 pIC50 17 nM IC50 J Med Chem (1998) 41: 4533-4541 [PMID:9804692]
ChEMBL Inhibition of partially purified dihydrofolate reductase (DHFR) from Toxoplasma gondii (Tg) B 7.77 pIC50 17 nM IC50 J Med Chem (2002) 45: 233-241 [PMID:11754594]
ChEMBL Inhibition of Dihydrofolate reductase of Toxoplasma gondii B 7.77 pIC50 17 nM IC50 J Med Chem (1994) 37: 4522-4528 [PMID:7799402]
ChEMBL Inhibitory activity against Toxoplasma gondii DHFR* B 7.77 pIC50 17 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibition of Toxoplasma gondii dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Compound was tested for inhibition activity against Toxoplasma gondii (Toxoplasma gondii) Dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1998) 41: 913-918 [PMID:9526565]
ChEMBL Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. B 7.77 pIC50 17 nM IC50 J Med Chem (1996) 39: 1836-1845 [PMID:8627607]
ChEMBL Inhibitory concentration against dihydrofolate reductase DHFR from Toxoplasma gondii B 7.77 pIC50 17 nM IC50 J Med Chem (2001) 44: 2391-2402 [PMID:11448221]
ChEMBL Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii B 7.96 pIC50 11 nM IC50 J Med Chem (1995) 38: 1778-1785 [PMID:7752201]
ChEMBL Inhibition of Toxoplasma gondii dihydrofolate reductase B 7.96 pIC50 11 nM IC50 J Med Chem (1993) 36: 3437-3443 [PMID:8230134]
ChEMBL Inhibition of Dihydrofolate Reductase of Toxoplasma gondii. B 7.96 pIC50 11 nM IC50 J Med Chem (1997) 40: 479-485 [PMID:9046338]
ChEMBL Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (tg) B 7.96 pIC50 11 nM IC50 J Med Chem (1997) 40: 470-478 [PMID:9046337]
ChEMBL Inhibition of dihydrofolate reductase (DHFR) from Toxoplasma gondii(tg) B 7.96 pIC50 11 nM IC50 J Med Chem (1999) 42: 2447-2455 [PMID:10395486]
ChEMBL Inhibition of Toxoplasma gondii (tc) Dihydrofolate reductase B 8 pIC50 10 nM IC50 J Med Chem (1995) 38: 2158-2165 [PMID:7783147]
ChEMBL Inhibition against Dihydrofolate reductase in Toxoplasma gondii B 8 pIC50 10 nM IC50 J Med Chem (1997) 40: 1173-1177 [PMID:9089339]
ChEMBL Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range: 4.0-4.6 B 8.37 pIC50 4.3 nM IC50 J Med Chem (2004) 47: 2475-2485 [PMID:15115391]
ChEMBL Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii B 8.37 pIC50 4.3 nM IC50 J Med Chem (2004) 47: 1475-1486 [PMID:14998335]
ChEMBL Inhibitory concentration against Toxoplasma gondii dihydrofolate reductase B 8.37 pIC50 4.3 nM IC50 Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078]
ChEMBL Inhibitory concentration against Toxoplasma gondii DHFR B 8.37 pIC50 4.3 nM IC50 J Med Chem (2005) 48: 4420-4431 [PMID:15974594]
dihydrofolate reductase/Dihydrofolate reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
ChEMBL Inhibitory activity against Leu22-Phe mutant human Dihydrofolate reductase B 7.42 pKi 38 nM Ki J Med Chem (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibitory activity against Wild-type human DHFR B 7.48 pKi 33 nM Ki J Med Chem (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibition of human recombinant Dihydrofolate reductase enzyme B 10.6 pKi 0.03 nM Ki J Med Chem (1996) 39: 892-903 [PMID:8632413]
ChEMBL Inhibition of human recombinant DHFR B 8.52 pIC50 3 nM IC50 J Med Chem (2013) 56: 4422-4441 [PMID:23627352]
ChEMBL In vitro inhibition of human dihydrofolate reductase B 8.7 pIC50 2 nM IC50 J Med Chem (1995) 38: 3608-3616 [PMID:7658448]
dihydrofolate reductase/Dihydrofolate reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2363] [GtoPdb: 2603] [UniProtKB: Q920D2]
ChEMBL Compound was tested for inhibition activity against rat liver lipophilic Dihydrofolate reductase (DHFR). B 7.82 pIC50 15 nM IC50 J Med Chem (1998) 41: 913-918 [PMID:9526565]
ChEMBL The ability to inhibit rat liver Dihydrofolate reductase was tested B 7.82 pIC50 15 nM IC50 J Med Chem (1999) 42: 1007-1017 [PMID:10090784]
ChEMBL Inhibition of rat liver dihydrofolate reductase B 8.36 pIC50 4.4 nM IC50 J Med Chem (2008) 51: 6195-6200 [PMID:18771252]
ChEMBL Inhibitory concentration against dihydrofolate reductase DHFR from rat liver. B 8.36 pIC50 4.4 nM IC50 J Med Chem (2001) 44: 2391-2402 [PMID:11448221]
ChEMBL Inhibition of rat liver DHFR B 8.48 pIC50 3.3 nM IC50 J Med Chem (2013) 56: 4422-4441 [PMID:23627352]
ChEMBL Inhibitory concentration against dihydrofolate reductase of rat liver B 8.48 pIC50 3.3 nM IC50 J Med Chem (2004) 47: 1475-1486 [PMID:14998335]
ChEMBL Inhibitory activity against rat dihydrofolate reductase B 8.48 pIC50 3.3 nM IC50 Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078]
ChEMBL Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range: 2.9-3.9 B 8.48 pIC50 3.3 nM IC50 J Med Chem (2004) 47: 2475-2485 [PMID:15115391]
ChEMBL Inhibition Dihydrohydrofolate reductase(DHFR) of rat liver B 8.48 pIC50 3.3 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibitory concentration against rat DHFR B 8.48 pIC50 3.3 nM IC50 J Med Chem (2005) 48: 4420-4431 [PMID:15974594]
ChEMBL Inhibitory activity against rat liver Dihydrofolate reductase B 8.82 pIC50 1.5 nM IC50 J Med Chem (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibition of dihydrofolate reductase (DHFR) from rat liver (rl) B 8.82 pIC50 1.5 nM IC50 J Med Chem (1999) 42: 2447-2455 [PMID:10395486]
ChEMBL Inhibition of dihydrofolate reductase from rat liver. B 8.82 pIC50 1.5 nM IC50 J Med Chem (2003) 46: 5074-5082 [PMID:14584957]
ChEMBL Inhibitory concentration against Rat liver Dihydrofolate reductase B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 1930-1936 [PMID:9191971]
ChEMBL Inhibitory concentration against rat liver dihydrofolate reductase (DHFR) B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Inhibitory activity against rat DHFR* B 8.82 pIC50 1.5 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Concentration inhibiting rat liver dihydrofolate reductase. B 8.82 pIC50 1.5 nM IC50 J Med Chem (1995) 38: 2615-2620 [PMID:7629801]
ChEMBL Inhibitory activity against rat liver dihydrofolate reductase B 8.82 pIC50 1.5 nM IC50 J Med Chem (1996) 39: 1271-1280 [PMID:8632434]
ChEMBL Inhibitory concentration against Dihydrofolate reductase from Rat liver (rl) B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 470-478 [PMID:9046337]
ChEMBL Inhibition of rat liver dihydrofolate reductase B 8.82 pIC50 1.5 nM IC50 J Med Chem (1993) 36: 3437-3443 [PMID:8230134]
ChEMBL Inhibition of Dihydrofolate Reductase of Rat Liver. B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 479-485 [PMID:9046338]
ChEMBL Inhibitory activity against Dihydrofolate reductase from rat liver was evaluated using 90 uM dihydrofolic acid as substrate B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 3040-3048 [PMID:9301666]
ChEMBL Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver B 8.82 pIC50 1.5 nM IC50 J Med Chem (1998) 41: 4533-4541 [PMID:9804692]
ChEMBL Inhibition of rat liver dihydrofolate reductase B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Inhibition of partially purified dihydrofolate reductase (DHFR) from rat liver B 8.82 pIC50 1.5 nM IC50 J Med Chem (2002) 45: 233-241 [PMID:11754594]
ChEMBL Inhibition of Dihydrofolate reductase (DHFR) of in rat liver B 8.82 pIC50 1.5 nM IC50 J Med Chem (1994) 37: 4522-4528 [PMID:7799402]
ChEMBL Inhibitory activity against rat liver dihydrofolate reductase. B 8.82 pIC50 1.5 nM IC50 J Med Chem (1996) 39: 1836-1845 [PMID:8627607]
ChEMBL Inhibition of rat liver dihydrofolate reductase. B 8.82 pIC50 1.5 nM IC50 J Med Chem (1993) 36: 3103-3112 [PMID:8230096]
ChEMBL Inhibitory activity against Dihydrofolate reductase from rat liver B 8.82 pIC50 1.5 nM IC50 J Med Chem (1995) 38: 1778-1785 [PMID:7752201]
ChEMBL Inhibition against Dihydrofolate reductase in rat liver B 9 pIC50 1 nM IC50 J Med Chem (1997) 40: 1173-1177 [PMID:9089339]
ChEMBL Inhibition of rat liver Dihydrofolate reductase B 9 pIC50 1 nM IC50 J Med Chem (1995) 38: 2158-2165 [PMID:7783147]
Dihydrofolate reductase in Pneumocystis jirovecii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2057] [UniProtKB: Q9UUP5]
ChEMBL Inhibition of Pneumocystis jirovecii recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and NADPH B 7.39 pIC50 41 nM IC50 Bioorg Med Chem (2018) 26: 2640-2650 [PMID:29691153]
Dihydrofolate reductase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2576] [UniProtKB: P07807]
ChEMBL Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. B 7.51 pIC50 31 nM IC50 J Med Chem (1996) 39: 1836-1845 [PMID:8627607]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]